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  • Elevated CPK .. trying Welchol now!

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    Old 07-08-2007, 05:52 AM   #1
    eagle50
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    Question Elevated CPK .. trying Welchol now!

    To make a very long story short ... i started treatment of High Cholestrol (which runs in my family) nearly 12 yrs ago! Well over 300 and ratio's and triglyc were also out of whack. Started on Zocor ... increased doses until that wasn't helping so I was switched to Lipitor (40 mg) .... and had been on that for around 5 yrs. The results were great .. as far as the cholesterol, ratios and trigl (combined with diet and excercise). But over the last few years ... unexplained muscle weakness. Many trips to Orthopedic Dr., family dr., Chiropractor and Massage Therapist .... never with any diagnosis .. all with temporary relief for verious aches, pains and leg cramps! It wasn't until a several months ago that I thought about a possible link to the statins. So I talked to my family doc about that ... and he tested for CPK and sure enough they were elevated! No surprise there!

    However ... since then we tested blood work several more time over a period of months ... off lipitor .. on zetia .. off everything ... tests by specialists ... EMG, etc .... no results (which I am happy about) .. but the CPK's all the while remain persistently elevated .. now at around 500 (had been much higher) .. not terribly high but high enough that the doc is concerned. We are baffled!

    In the meantime .. my cholesterol went sky high again ... of course ... not being on any medication ... so we are now trying WelChol.

    What next or should I ignore the elevated CPK? Maybe some people (like me) just normally have high CPK's. Any thoughts? Has anyone been through similiar situation with the CPK's?

    Last edited by eagle50; 07-08-2007 at 05:57 AM. Reason: spell check and clarification

     
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    Old 07-08-2007, 07:36 AM   #2
    Lenin
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    Re: Elevated CPK .. trying Welchol now!

    With the reading of 500, there is probably some muscle damage going on but that damage can come from hard exercise breaking down muscle tissue.
    CPK readings for statin induced rhabdomyolysis are usually in the tens of thousands.
    John's Hopkins calls any level below 250 normal.

    A lot of people with fibromyalgia have readings like yours. Other causes:
    drugs (prescription and illicit), trauma (temporary elevation of CPK), inflammation (myositis), alcohol, genetic problems with the muscle, viral infections.
    Perhaps a visit to a rheumatologist is a good idea.

    A study of applicants for the Johnson Space Center Program (astronaut wannabees) showed 16% with CPK's over the upper "normal" limit.

    Before your next test, why not spend a week being EXTREMELY sedentary and don't take ANY drugs...even aspirin raises CPK.

    Of course, always be on the lookout for brown urine.

    Last edited by Lenin; 07-08-2007 at 07:40 AM.

     
    Old 07-08-2007, 08:10 AM   #3
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    Lightbulb Re: Elevated CPK .. trying Welchol now!

    Good luck with the welchol, it didn't help me. The thing that caught my attention was the "on Zetia". They still have me messed up with the cpk count "1600" and hurting. The Zetia will raise your cpk too. They'll tell you it won't but it does. I was floored when my endocrinologist told me that .Thats the reason I say endocrinologist, is my cardiologist sent me to her to find out why my cpk would not go down. That's when I found out Zetia will raise Cpk.

    Hope this helps.
    Allen

     
    Old 07-09-2007, 04:23 AM   #4
    Lenin
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    Re: Elevated CPK .. trying Welchol now!

    I am beginning to think that Zetia may be even harder on the body than statins.

     
    Old 07-09-2007, 07:55 AM   #5
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    Re: Elevated CPK .. trying Welchol now!

    O.K. guys, this neophyte needs to know what "CPK" stands for?
    Sorry........

     
    Old 07-09-2007, 08:31 AM   #6
    Guy1_USA
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    Re: Elevated CPK .. trying Welchol now!

    Quote:
    Originally Posted by Lenin View Post
    I am beginning to think that Zetia may be even harder on the body than statins.


    I have heard folks say this. Why do you say this... are you taking Zetia...?

     
    Old 07-10-2007, 04:45 AM   #7
    Lenin
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    Re: Elevated CPK .. trying Welchol now!

    Quote:
    Originally Posted by Mr. Detail View Post
    O.K. guys, this neophyte needs to know what "CPK" stands for?
    Sorry........
    CPK (or CK) stands for creatine phosphokinase, an enzyme that is released into the blood whenever tissue damage occurs. There are three types that can be differentiated to tell whether the damage was to skeletal muscle, heart musce or tissue damage.
    Trouble with CPK uis that it is not very specific and LOTS of life's normal insults will raise it.

    Venture Man,
    No, the closest I ever got to Zetia was my GP wanting me to get LDL's in the 60's instead of the 80's so he said I should either double my Lipitor or try Vytorin (Zetia and Zocor.) I upped the Lipitor (and succeeded) and have a couple boxes of Vytorin samples in my drawer which I may or may not try down the road. My comment about Zetia is mostly from people reporting here and elsewhere about their use of Zetia.
    My thinking is that if Lipitor + Niacin NEVER gives me problems why risk that situation by adding another potentially liver-toxic drug.

    Last edited by Lenin; 07-10-2007 at 04:46 AM.

     
    Old 07-10-2007, 07:39 PM   #8
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    Re: Elevated CPK .. trying Welchol now!

    Thanks for some of the insight regarding CPK and potential causes. I have seen a rheumatologist ... no answers ... the only thing that hasn't been done yet is a muscle biopsy .. but we will likley hold off on that. And regarding Zetia ... it did not lower my chol or CPK's ! I have been taking an 81 mg aspirin daily for many years ... maybe its as simple as that ... CPK of 500 not a big deal I guess. I think I am just going to focus on the HDL's and LDL's for now and not worry about the CPK's. Thanks

     
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