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    Old 03-05-2004, 06:43 PM   #1
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    drug half life


    I had a horrible facial flushing/intense hot red ear reaction from Lotrel and my blood pressuer woul spike way up.... I stopped taking it, and within about 8 days the flashes were gone BUT occasionally after 6 weeks, I still get some red ear/facial flushing. Could the half life of anything in this drug be that long???

    i also had the 24 urine test for pheochromocytoma since my doc INSISTED it wasn't the drug.

    i fired her, by the way


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    Old 03-06-2004, 07:12 AM   #2
    Join Date: Apr 2002
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    Re: drug half life


    The offending agent in Lotrel was probably the amlopidine (Norvasc). This calcium channel blocker has an extremely long half life indeed (30-50) hours, but after 6 weeks I'm sure its gone enought to have only miniscule amounts left. It took me a couple weeks to stop feeling the Norvasc!

    I had trouble with nadolol a long time ago with it's 72 hour half life, but 2 weeks pretty much did the job.

    (For record keepsers, a metabolite of Plavix (clopidogrel) has an active half life of 3 WEEKS)

    Old 03-06-2004, 07:32 AM   #3
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    Re: drug half life

    What are you two referring to by the term, "drug half life"?

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