It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....



High & Low Blood Pressure Message Board

  • Norvasc 5mg + Zebeta 2.5mg when it will start working?

  • Post New Thread   Closed Thread
    Thread Tools Search this Thread
    Old 12-03-2007, 07:08 PM   #1
    cartner
    Senior Veteran
    (male)
     
    cartner's Avatar
     
    Join Date: Sep 2005
    Location: Egypt
    Posts: 1,671
    cartner HB Usercartner HB Usercartner HB Usercartner HB Usercartner HB Usercartner HB User
    Norvasc 5mg + Zebeta 2.5mg when it will start working?

    Hi,

    Few days back I was switched to Norvasc 5mg (taken at 9:00 PM) + Zebeta 2.5mg (taken at 9:00 AM). When I should see decrease in my blood pressure? 1 week?
    I was on Diltiazem before so I guess that replacing one CCB with another is not a big deal for the body.
    Thanks for help,
    Michael

     
    Sponsors Lightbulb
       
    Old 12-05-2007, 08:52 AM   #2
    flowergirl2day
    Senior Veteran
    (female)
     
    Join Date: Apr 2007
    Location: Canada
    Posts: 3,181
    flowergirl2day HB Userflowergirl2day HB Userflowergirl2day HB Userflowergirl2day HB Userflowergirl2day HB Userflowergirl2day HB User
    Re: Norvasc 5mg + Zebeta 2.5mg when it will start working?

    Michael,

    Be patient. You should start seeing a reduction in your blood pressure anytime now.

    According to my favorite drug book, two to four weeks of therapy are needed in patients just initiating the drug therapy with Norvasc. You'd been on a similar medication prior so I am sure it won't take as long to see benefits in blood pressure control. It is stressed that the lowest possible dose that works be used for long term blood pressure control with periodic evaluations, including ECGs, a MUST. As with other CCBs, there can be changes in heart rate and heart rhythm irregularities. One word of caution - these types of things are even more likely with concurrent use of the beta blockers.
    Interestingly, this medication improves the ability to be more active without resulting in angina pain - so it may actually help with the exercise tolerance reduction caused by our beta blockers.

    As for Zebeta (Bisoprolol), blood pressure response is seen within a week in patients starting the therapy. You should be seeing a good reduction in blood pressure anytime now. One thing to remember is that to retain its cardioselectivity, it is important to use the LOWEST effective dose of this drug. The selectivity is not absolute and at higher doses (>20mg) the beta2 receptors in the bronchial and vascular tissue are also inhibited. Which is not what we want if I want to be able to breathe and you exercise.

    Good luck and keep us posted!

    flowergirl

     
    Old 12-07-2007, 07:44 AM   #3
    cartner
    Senior Veteran
    (male)
     
    cartner's Avatar
     
    Join Date: Sep 2005
    Location: Egypt
    Posts: 1,671
    cartner HB Usercartner HB Usercartner HB Usercartner HB Usercartner HB Usercartner HB User
    Re: Norvasc 5mg + Zebeta 2.5mg when it will start working?

    Hi flowergirl,

    Sorry but I have some problems with my internet connection .
    Anyway, my blood pressure today is 120/84 (for the first time in a cold day). So I guess I will be fine, but I have one problem . My heart rate ranges from 48 to 60, I don't know what I should do, maybe it's because I have been on Magnesium supplements for 2 years (250mg daily) until I stopped it because of Zebeta?? maybe it's addictive?
    What do you think?
    I'm doing to see my dr soon, because I'm on Effexor XR 75mg and Xanax 0.5mg daily for Depression and Anxiety.
    Thanks for help,
    Michael

     
    Old 12-08-2007, 04:35 AM   #4
    cartner
    Senior Veteran
    (male)
     
    cartner's Avatar
     
    Join Date: Sep 2005
    Location: Egypt
    Posts: 1,671
    cartner HB Usercartner HB Usercartner HB Usercartner HB Usercartner HB Usercartner HB User
    Re: Norvasc 5mg + Zebeta 2.5mg when it will start working?

    Today I forgot to take my 2.5mg Zebeta, I feel better and my pulse is between 66 - 72. I'm very depressed . I have tried many meds and nothing works without side effects, except for CCBs. I think I will ask my dr to up my dose to 10mg of Norvasc, if that will never work. I have tried Atacand and Cozaar in the ARB family, I got the same side effects from trying both. I wonder if I would get the same side effects trying other drugs in the same class?
    Thanks,
    Michael

     
    Old 12-08-2007, 07:07 PM   #5
    flowergirl2day
    Senior Veteran
    (female)
     
    Join Date: Apr 2007
    Location: Canada
    Posts: 3,181
    flowergirl2day HB Userflowergirl2day HB Userflowergirl2day HB Userflowergirl2day HB Userflowergirl2day HB Userflowergirl2day HB User
    Re: Norvasc 5mg + Zebeta 2.5mg when it will start working?

    Michael,

    Sorry to hear about your depression and the side effects of your meds.
    I think the problem here (side effects) may be due to the interactions between your medications.

    Xanax and Zebeta (Bisoprolol): the coadministration of hypotensive (blood pressure) and psychotherapeutic (antidepressants) agents increases hypotensive and depressant effects. Additive effects result in drowsiness and dizziness. People should be monitored for hypotension and excessive and prolonged depression.

    Xanax and Effexor: Central nervous system depression and respiratory effects increased. People should be monitored for depression and also respiratory depression.

    Bisoprolol and Effexor - additive effects

    Xanax and magnesium - minor interaction (delayed GI absorption)
    Bisoprolol and magnesium - oral magnesium decreases bioavailability of beta blockers

    It would be great if your doctor allowed you to get off the antidepressants. They only perpetuate the problem of depression. They also contribute to your side effects through their interactions with the blood pressure meds. Some of your medications have additive effects when combined with the others. This means that your body is affected by them to a much greater extent than intended with the dosage prescribed. I have been dealing with the same thing.

    Magnesium has a depressant effect on the central nervous system. Perhaps your depression was partly caused by your magnesium supplementation. I don't know how strong the dose needs to be to affect people in this way. Magnesium produces vasodilation. Low doses can result in flushing and sweating, larger doses lower blood pressure. I don't know what you make of all this. In general, the more medication a person takes, the greater the occurence and intensity of side effects. (At least in my experience). It is possible that without the antidepressants, your side effects from the CCB & BB could be minimal and well tolerated. Only your doctor knows whether or not you need this medication. You should have a discussion with him about your depression and its presumed causes.

    flowergirl

     
    Old 12-08-2007, 07:18 PM   #6
    flowergirl2day
    Senior Veteran
    (female)
     
    Join Date: Apr 2007
    Location: Canada
    Posts: 3,181
    flowergirl2day HB Userflowergirl2day HB Userflowergirl2day HB Userflowergirl2day HB Userflowergirl2day HB Userflowergirl2day HB User
    Re: Norvasc 5mg + Zebeta 2.5mg when it will start working?

    One thing I forgot to mention: there is another ARB that I've heard a lot of good things about on this board. It's called Avapro. If I were to try another ARB after two failed attempts (Micardis and Diovan), I'd try that one. I think you should hold off on changing medication again. You need to give it more time to work, unless your side effects have become intolerable.

    If you want to avoid some very unpleasant side effects, think twice about having your Norvasc increased to 10mgs! Studies compared the frequency of reported side effects of CCBs in 2.5, 5 and 10mg doses. Guess what dose had the highest incidence of side-effects? You'll be glad to hear people taking Norvasc had fewer side effects on any dose than did people taking my CCB, Felodipine.

    flowergirl

    Last edited by flowergirl2day; 12-08-2007 at 09:41 PM.

     
    Old 12-09-2007, 08:09 AM   #7
    cartner
    Senior Veteran
    (male)
     
    cartner's Avatar
     
    Join Date: Sep 2005
    Location: Egypt
    Posts: 1,671
    cartner HB Usercartner HB Usercartner HB Usercartner HB Usercartner HB Usercartner HB User
    Re: Norvasc 5mg + Zebeta 2.5mg when it will start working?

    Quote:
    Originally Posted by flowergirl2day View Post
    One thing I forgot to mention: there is another ARB that I've heard a lot of good things about on this board. It's called Avapro. If I were to try another ARB after two failed attempts (Micardis and Diovan), I'd try that one. I think you should hold off on changing medication again. You need to give it more time to work, unless your side effects have become intolerable.

    If you want to avoid some very unpleasant side effects, think twice about having your Norvasc increased to 10mgs! Studies compared the frequency of reported side effects of CCBs in 2.5, 5 and 10mg doses. Guess what dose had the highest incidence of side-effects? You'll be glad to hear people taking Norvasc had fewer side effects on any dose than did people taking my CCB, Felodipine.

    flowergirl
    Sorry but I don't understand what did you mean by thinking twice about increasing the dose of Norvasc to 10mg? it's a bad thing? It seems that this is the best drug class I have used so far.

    About ARBs, I experienced the same side effects from both Cozaar and Atacand . Do I expect Avapro to be any different?

    Actually, I have Depression and Anxiety since I was a kid but I didn't want to admit that. I need those medications, in Effexor XR leaflet they say that the side effects I'm having (dizziness, nausea, yawning, tired all day long) will disappear gradually in 8 weeks.

    Today at 12:00 PM my BP was 110/90, and now (6:00 PM) it's 140/95. I take Norvasc around 10:00 PM daily. I'm going to wait more few days and take more readings, by the way Effexor and Xanax has no effects on my blood pressure at all (thank god ).

    One more thing, since I have started Effexor (around 16 days ago) I lost 9 lbs . I think that in the next 4 months I would lose my extra 25 lbs.

    I stopped taking Magnesium supplements.
    Thanks for your help and for your great information, and I'm sorry if I'm wasting more of your time but I really need help .
    Michael

    Last edited by cartner; 12-09-2007 at 08:11 AM.

     
    Old 12-09-2007, 07:59 PM   #8
    flowergirl2day
    Senior Veteran
    (female)
     
    Join Date: Apr 2007
    Location: Canada
    Posts: 3,181
    flowergirl2day HB Userflowergirl2day HB Userflowergirl2day HB Userflowergirl2day HB Userflowergirl2day HB Userflowergirl2day HB User
    Re: Norvasc 5mg + Zebeta 2.5mg when it will start working?

    Michael,

    Quote:
    Sorry but I don't understand what did you mean by thinking twice about increasing the dose of Norvasc to 10mg? it's a bad thing? It seems that this is the best drug class I have used so far
    I am glad this medication works well for you. All I meant was that the side effects are dose related. The higher the dose, the more likely a person is to develop side effects. While you may tolerate a 5mg dose very well, 10mg is twice as much medication. I had to have my dosage decreased from 10mg to 5mg because of intolerable side effects. This dose adjustment resulted in milder side effects but also a blood pressure increase. Another medication had to be added to make up for the difference. After a while, my blood pressure readings started being high again. For this reason my dose of the CCB was recently increased back to 10mg. It seems to have worked so far, except for this last week or so.

    Quote:
    About ARBs, I experienced the same side effects from both Cozaar and Atacand . Do I expect Avapro to be any different?
    I have no experience with this one. Your guess is as good as mine. I am willing to try it someday. Trying it is the only way to find out if I am allergic to the entire drug class. Any side effects should be mild.

    I know too well how frustrating trying to get the blood pressure controlled can be. Unfortunately, most medications have side effects. Looking for one that works well and whose side effects you can tolerate and live with takes time. The fact that you have to remain on strong antidepressants makes your goal of living without any side effects more difficult to achieve. I am glad your other meds don't seem to be affecting your blood pressure. Your readings seem pretty good, given how much our blood pressure varies during the day. I don't think you'll miss the magnesium too much. I know you work hard every day to get fit and stay healthy. If your weight loss is anticipated.......good for you! With the loss of excess weight you'll have lower blood pressure readings. The dosage of your medications will need to be adjusted.
    Are you saying you think the new medication is responsible for your weight loss? If that's the case, you must mention this to your doctor! The drug could be interfering with the digestion of your food, metabolism or the absorption of nutrients. Not good. Check the drug info sheet that came with it for any such side effects.

    flowergirl

    Last edited by flowergirl2day; 12-09-2007 at 08:02 PM.

     
    Old 12-10-2007, 03:58 AM   #9
    cartner
    Senior Veteran
    (male)
     
    cartner's Avatar
     
    Join Date: Sep 2005
    Location: Egypt
    Posts: 1,671
    cartner HB Usercartner HB Usercartner HB Usercartner HB Usercartner HB Usercartner HB User
    Re: Norvasc 5mg + Zebeta 2.5mg when it will start working?

    Actually, Effexor makes me eat less that's why I'm losing weight. I know that everyone is different, because many people got a lot of extra weight being on Effexor.

    I remember when I started Diltiazem I got a little dizzy, weak and I have had headache for about 2 weeks. After that everything was fine, I wonder if the same applies to ACEs. I got VERY tired and dizzy and I stopped using the Meds (ACEs or ARBs) after few days. I didn't wait to see if things will get better or not.

    Thanks for your great help and wish me luck. I know it will take time to search for the right combination but I'm going to do it. Also, I'm going to ask my dr to increase Norvasc to 10mg and see if I will get side effects.

    Thanks again,
    Michael

     
    Closed Thread

    Related Topics
    Thread Thread Starter Board Replies Last Post
    Should I wean off Norvasc? cartner High & Low Blood Pressure 7 06-07-2008 06:13 PM
    Switching back to Diltiazem SR from Norvasc cartner High & Low Blood Pressure 0 06-07-2008 03:41 PM
    off Toporol :) now working on Norvasc 10sboi High & Low Blood Pressure 5 03-19-2008 03:53 PM
    Switched from Diltiazem 240mg SR to 10mg of Norvasc, BP is 130/78 cartner High & Low Blood Pressure 19 01-01-2008 07:17 PM
    Norvasc feedback?? arlmon18 High & Low Blood Pressure 11 09-02-2006 01:02 PM
    does the body adjust to Norvasc? cartner High & Low Blood Pressure 4 12-14-2005 09:17 AM
    Norvasc: Tell us your experience please. cartner High & Low Blood Pressure 16 10-25-2005 08:53 AM




    Thread Tools Search this Thread
    Search this Thread:

    Advanced Search

    Posting Rules
    You may not post new threads
    You may not post replies
    You may not post attachments
    You may not edit your posts

    BB code is On
    Smilies are On
    [IMG] code is Off
    HTML code is Off
    Trackbacks are Off
    Pingbacks are Off
    Refbacks are Off




    Sign Up Today!

    Ask our community of thousands of members your health questions, and learn from others experiences. Join the conversation!

    I want my free account

    All times are GMT -7. The time now is 05:34 AM.





    © 2020 MH Sub I, LLC dba Internet Brands. All rights reserved.
    Do not copy or redistribute in any form!