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Does norvasc contain sulfur

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Old 03-01-2009, 09:55 AM   #1
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Does norvasc contain sulfur

Does norvasc contain sulfur

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Old 03-02-2009, 12:04 AM   #2
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Re: Does norvasc contain sulfur


the (preferred) chemical composition of Norvasc is:

Active ingredient: amlodipine besylate, corresponding to either 5 or 10mg of amlodipine base

sodium starch glycollate - a disintegrant
microcrystalline cellulose - a compression aid
magnesium stearate - a lubricant
dibasic calcium phosphate - an additive that provides sheen

Besylate salt is the same as benzene sulphonate salt. During the manufacturing process, they prepare this salt by reacting the amlodipine base with a solution of benzenesulphonic acid in an inert solvent (a methylated spirit).
Sulfonic acid...A.K.A. benzemonosulfonic acid... is considered a synthetic intermediary for sulpha drugs.
Sulfur, sulfite and sulfates are not likely to cause problems for people with a sulfa allergy. There are some drugs that are related to sulfonamides- such as a diuretic hctz- that can cause problems in some people. The drugs to watch for if one has a sulfa allergy are sulfa antibiotics, some diabetes medications, sulfasalasine for IBD, some COX 2 inhibitors and some migraine medication. The BEST source of information is your pharmacist - always check with him/her. They know everything (well, their databases do!!!)

P.S. I checked a list of sulpha drugs in one of my books just to be sure - Norvasc is not on it. That does not mean that some people won't react adversely to this medication. Talk to your pharmacist.


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