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elevated ALT/GGT - what does this mean

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Old 01-19-2006, 10:41 PM   #1
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elevated ALT/GGT - what does this mean

What does this mean when these are the only high enzyme counts in a blood test. If you can find the post "what is wrong with me?" you will see my symptoms. I'm just curious if ALT in conjunction with GGT levels mean anything.

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Old 01-20-2006, 05:55 AM   #2
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Re: elevated ALT/GGT - what does this mean

Gamma-glytamyl transpeptidase is an enzyme which is found in hepatocytes and biliary epithelial cells. GGT may be high in liver disease. In particular it is a feature of biliary outflow obstruction rather than hepatocellular damage.

* GGT (in men) = 11 - 50 i.u./l
* GGT (in women) = 7 - 32 i.u./l

Note reference ranges may vary between laboratories.

GGT serum measurement provides a very sensitive indicator of the presence or absence of hepatobiliary disease. However the usefulness of measurement of serum GGT is limited by its lack of specificity. Raised GGT levels have been reported in a variety of clinical conditions including (1):

* pancreatic disease
* myocardial infarction
* chronic obstructive pulmonary disease
* renal failure
* diabetes
* alcoholism

Drugs such as phenytoin and barbiturates may cause high GGT levels (2).

The reported sensitivity of a raised GGT for detecting alcohol ingestion has ranged from 52% to 94% (3,4).

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