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Greatly elevated enzymes, but no symptoms and all negative tests

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Old 01-13-2012, 10:37 AM   #1
Join Date: Jan 2012
Location: Chicago
Posts: 2
Noshguy HB User
Greatly elevated enzymes, but no symptoms and all negative tests


New to the board,but looking for some thoughts. My wife recently had a blood test done to qualify for insurance. Here liver enzyme levels came back really high. I don't have those exact numbers, but a few weeks later she coincidentally had another blood test for a work wellness program. I know the numbers were much lower, but still really high. Those numbers were:
GGT - 312
AST - 98
ALT - 147

I want to say the GGT was only slightly lower, but the AST and ALT were around half as much. So the first test may have been like 330 GGT, 200 AST, and 300 ALT. Or something around there.

We can immediately rule out lifestyle causes. She's not a drinker, no wierd diets, no rapid weight loss. She has absolutely zero symptoms. No pain. No bowel problems. We wouldn't even know about this if not for it showing up in a blood test that we assumed would be clean.

So she went to the doctor and he ran another blood test. This third test is about 7 weeks from the first, and 4 weeks from the second. This time, the AST and ALT were again lower. Still above the 0-40 normal range, but not by much. GGT was lower, but still elevated. I don't have the exact numbers but I want to say the GGT was in the 150 range maybe?

She had a CT Scan with contrast done, and blood tests for an array of disorders. CT shows no cancer. Blood tests show negative for everything (hep b, hep c, etc...etc...). The only possible one was the Lupus test showed numbers that were right on the high end of the normal range. So maybe something there. Thyroid is fine, hep a is fine.

3 weeks later (now 2.5 months from the first test) they ran another blood test. AST and ALT are now barely over the range. GGT is still quite elevated however.

So now she's off to a specialist.


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Old 01-14-2012, 05:51 AM   #2
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Join Date: Jan 2012
Location: Alabama
Posts: 134
pbt140 HB Userpbt140 HB Userpbt140 HB Userpbt140 HB User
Re: Greatly elevated enzymes, but no symptoms and all negative tests

Is your wife on birth control or anti-depression meds? These are causes of higher increase in the GGT.
Also unlike other liver test- your should not eat or drink anything for about 8 hours before the test.
Alot of docs just run a regular liver test that requires no fasting. but when a GGT test is performed it should be done with no eating or drinking for many hours before the test.

Old 01-16-2012, 07:22 AM   #3
Join Date: Jan 2012
Location: Chicago
Posts: 2
Noshguy HB User
Re: Greatly elevated enzymes, but no symptoms and all negative tests

She ended birth control a couple weeks prior to the first test. She immediately started prenatal vitamins. No other medication.

The first two blood test were taken while fasting, since they were complete panels looking at blood sugar and whatnot. Then the CT scan and associated blood test were taken under the CT scan procedure of drinking the contrast drinks (chalk water stuff). The last blood test was not taken while fasting.

I was looking into something called NASH. That sort of makes sense. My wife adopted my horrible diet lifestyle when we got married and has put on 50 lbs or so. Unfortunately, it all went to her stomach area. She looks pregnent, basically. We understand that the stomach area is the worst place to carry the fat. Perhaps she just has some fatness induced "fatty liver" going on. She also jumped over the boundries in glucose (106, range is 65-99) and LDL (167, range is 0-129). It does seem strange that if they're related, that LDL jumps to being 30% over the limit but GGT jumps to 420% over the limit.

We've said goodbye to the relaxed lifestyle of eating whatever we want and never working out, and we're on track to get back in shape this year.

I guess there's nothing to do but talk to the specialist and try not to go insane before then. I just hold on to the fact that all the nasty outcomes (cancer, hepatitis, etc...) all came back clearly negative.


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