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  • Drug-induced lupus??

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    Old 12-06-2006, 04:04 PM   #1
    pearlandmary
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    Red face Drug-induced lupus??

    Has anyone gotten lupus because of a certain drug they were taking?
    I just read on Web-MD that certain drugs can trigger lupus and am wondering if anyone has gone thur this and if when you stopped taking that drug, did it go away? My daughter who is 27 just was diagnosed and she takes Dilantin which is one of the drugs that triggers lupus. Now Im thinking that ,thats why she now has lupus.

    thanks
    Mary

     
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    Old 12-07-2006, 05:17 AM   #2
    VeeJ
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    Re: Drug-induced lupus??

    Hi. I'm sorry your daughter has been diagnosed with lupus. I looked up Dilantin & I found that it's an anti-seizure medication. (Did I get this right?) The thing is, lupus itself can cause seizure activity in people with lupus central nervous system (CNS) involvement. Further, antiphospholipid syndrome, the "sticky blood" clotting disorder seen in a fair number of lupus patients, can ALSO cause seizure activity.

    (An aside: I myself didn't see Dilantin listed as a possible DILE candidate, but that doesn't say much. I think various resources list different drugs.)

    Symptoms of lupus & antiphospholipid syndrome are listed in several "sticky posts" at the top of the thread list here. Plus, another "sticky" cites a resource that has extensive info on lupus test results.

    Elsewhere I've read that DILE will typically resolve when the offending drug is discontinued. I've also read that somewhat different autoantibody tests are more likely to be positive in DILE, versus others being more likely indicative of "classic" SLE. Do you know which particular tests in your daughter's bloodwork results were positive?

    Also, there are several excellent hardcovers on lupus in most libraries & bookstores that might help both of you. One is by a Dr. Daniel Wallace, and there are several by a Dr. Robert Lahita.

    I'm guessing that distinguishing DILE from SLE is not simple. I've read that certain drugs are more implicated in DILE, some less, some implicated very rarely, etc. But I still suspect that such "drug odds" are far from being "drug rules". For example, maybe the same drug that caused DILE in one person, could, in another person, worsen lupus that is ALREADY present, whether previously Dx'ed or not. What sort of specialists is your daughter seeing? Have they commented on the Dilantin?

    I hope you & your daughter keep posting. And that other people here chip in, too. Best wishes to you both! Bye for now, Sincerely, Vee.

     
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