It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....

Lupus Message Board

methotrexate and leucovorin

Post New Thread   Closed Thread
LinkBack Thread Tools Search this Thread
Old 07-07-2007, 10:48 AM   #1
Senior Member
Join Date: Mar 2005
Posts: 238
cookingmom HB User
methotrexate and leucovorin

Just wondering if any is taking the combination of methotrexate and leucovorin? I had to go off of the Plaquenil due to myopathy. When my symptoms started to get worse and worse, my rheumy added leucovorin to my meth. I take them on the same day each week but 12 hours apart. I feel slightly nauseated all the time (not enough to keep me from eating) and I feel like I get tired so much more quickly. I thought I would ask if any one else has taken this combo and if so, how did it work for you.

Thank you, Bern

Sponsors Lightbulb
Old 07-07-2007, 02:04 PM   #2
Join Date: Apr 2005
Location: TX
Posts: 331
ErinS64 HB User
Re: methotrexate and leucovorin

From what I have read this is a type of folic acid. I took that as well with the methotrexate. It is used to help with the side effects of the methotrexate and keep down the bad side effects.

In the end the MTX didnt work well for me. I hope you have better luck with it.

Dallas TX

Old 07-07-2007, 07:31 PM   #3
Junior Member
Join Date: Dec 2006
Location: NH
Posts: 33
NHCasey HB User
Re: methotrexate and leucovorin

Hi, I'm on 20 mg of MTX and the Leucovorin too...along with other drugs.

My doctor added the Leucovorin to hopefully stop he hair's not working yet.

Old 07-20-2007, 09:52 AM   #4
Join Date: Apr 2006
Location: Eastern US
Posts: 60
gina9871 HB User
Re: methotrexate and leucovorin

Yes, I am on 20 mg of mtx and take leukovorin 24 hrs after the mtx. It is a folic acid that is supposed to prevent the continued absorbtion of the mtx into the system which could be potentially harmful to the "good" cells in the body. The mtx reaches it's maximum efficacy in the first 12-24 hrs after ingestion, so the folic/leukovorin is kind of like a reversal/rescue drug of sorts. I don't have a lupus dx but a lupus-like Connective Tissue Disease. The mtx worked well for me in the first 3 months but it's not been able to get me into remission. My rheumy is battling my insurance co to also get me on Enbrel injections along with the mtx right now.
I don't get nauseous on the mtx any longer and it was only very minor to begin with (been on it since Jan.07) but I'd hate to think how badly I'd feel without the mtx. Plaquenil wasn't helpful in my situation. I'm still on 10 mg of prednisone and it's my saving grace along with celebrex.
I had some minor hair loss with my illness even before I started any meds and that hasn't changed even with the mtx - I'm still sort of "shedding" - but I had a lot of hair to begin with
Good luck to you.

Closed Thread

Similar Threads
Thread Thread Starter Board Replies Last Post
Methotrexate vs plaquenil side effects long term and short term mysteria Arthritis 4 11-17-2009 11:25 AM
Methotrexate... louisagerard Arthritis 5 06-07-2009 11:40 PM
Scared to start Methotrexate MegHurts Arthritis 6 05-18-2009 04:49 PM
Methotrexate Kathryn Arthritis 3 05-07-2009 08:35 AM
how long does the nausea last with methotrexate Lisa60 Arthritis 4 02-23-2009 11:58 AM
Question about Methotrexate kab031550 Arthritis 17 06-25-2007 09:10 AM
methotrexate for cough? kassy Lung & Respiratory Disorders / COPD 1 01-24-2006 12:08 AM
methotrexate tinav Lupus 12 05-21-2005 04:54 AM
methotrexate is not working MacBobbie Arthritis 2 03-17-2005 08:39 AM

Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is Off
HTML code is Off
Trackbacks are Off
Pingbacks are Off
Refbacks are Off

Sign Up Today!

Ask our community of thousands of members your health questions, and learn from others experiences. Join the conversation!

I want my free account

All times are GMT -7. The time now is 05:37 AM.

Site owned and operated by HealthBoards.comô
© 1998-2018 HealthBoards.comô All rights reserved.
Do not copy or redistribute in any form!