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Any difference with Brand Plaquenil or Generic

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Old 08-17-2009, 02:47 PM   #1
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Any difference with Brand Plaquenil or Generic

Hi Everyone,

I hope that everyone is hanging in there. Back in April i started to take the (Brand )Plaquenil because I am allergic to Sulfa. I had read that it was better to take the Brand if you were allergic to Sulfa. And thank goodness , I have done well with it so far. I was started on a small dose , 1\2 tablet a day , but now the Rheumie wants me to take 400 mg a day. I have cutaneous lupus. The brand has become quite expensive for me and I want to try taking the generic , but i am scared I will have an allergic reactions. Has anyone had any issues concerning the brand versus / generic ? Thank you.


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Old 08-18-2009, 12:23 PM   #2
Angel MJ
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Re: Any difference with Brand Plaquenil or Generic

hi again rosie13!
personally i have had reactions to generics ... i had reaction to the brand ones too ... but we are all individual. i would put that exact question to your doc

Originally Posted by rosie13 View Post
The brand has become quite expensive for me and I want to try taking the generic , but i am scared I will have an allergic reactions. Has anyone had any issues concerning the brand versus / generic ? Thank you.

Old 08-20-2009, 06:28 PM   #3
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watoozie HB User
Re: Any difference with Brand Plaquenil or Generic

I have been on the generic for 4 1/2 years, 400mg a day and I've had no problems. In fact I wouldn't want to be without it!! I sure don't want to feel like I did before the generic Plaquenil. I make sure I take 200mg with breakfast and 200mg with supper.

Old 08-21-2009, 01:19 PM   #4
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Re: Any difference with Brand Plaquenil or Generic

Hi Rosie,

I was on the generic for less than a year and had to switch to the name brand because of intense itching and rashes. I did not realize the generic had Sulfa in it and I am allergic to Sulfa. No wonder!

Also, after over two years of being on the name brand I had to get off it for the same allergic reaction. Ironically, in April I was hospitalized and they didn't have the name brand available so I went without it for 2 days. When I tried to take the name brand again I started getting the same intense itching and rashes. I am no longer on plaquenil and am now on injectable methotrexate.

I know the name-brand is expensive, but if it works, you might try to stay on it. It isn't a chemo agent like the methotrexate and other DMARDS, so it is more preferrable. Good luck and keep us posted!

Old 09-06-2009, 05:29 AM   #5
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Re: Any difference with Brand Plaquenil or Generic

Many drugs contain I have researched this fact I came up with a list of certain drugs that trigger lupus & other "suspect" drugs....these were found on *****
Drugs that cause drug-induced lupus erythematosus are as follows:
• Acebutolol
• Amiodarone
• Bupropion
• Captopril
• Carbamazepine
• Chlorpromazine
• Diltiazem
• Docetaxel
• Ethosuximide
• Gemfibrozil
• Glyburide
• Gold salt
• Griseofulvin
• Hydantoins
• Hydralazine
• Hydroxychloroquine (this is one that I am currently on)??? gonna print this article for my DOC!!!!
• Interferons
• Interleukins
• Isoniazid
• Leuprolide acetate
• Lithium
• Lovastatin
• Mephenytoin
• Methyldopa
• Minocycline
• Nitrofurantoin
• Olanzapine
• Ophthalmic timolol
• Oral contraceptives
• Penicillamine
• Phenytoin
• Practolol
• Procainamide
• Propylthiouracil
• Quinidine
• Reserpine
• Rifampin
• Sertraline2
• Simvastatin
• Sulfasalazine
• Tetracycline
• Ticlopidine
• Tiotropium bromide inhaler
• Trimethadione
• Tumor necrosis factor (TNF)3
• Valproate
• Voriconazole
Drugs that cause flares of SLE are as follows:
• Cimetidine
• Hydralazine
• Hydrochlorothiazide
• Mesantoin
• P -Aminobenzoic acid (PABA)
• Penicillin(I have taken this drug for repeat throat & ear infections)
• Phenylbutazone
• Sulfonamides(This drug I was on for repeat kidney infections)
• Terbinafine

Several broad drug categories have been linked to drug-induced lupus erythematosus, including the following:
• Antiarrhythmics - Procainamide and quinidine
• Antibiotics - Minocycline and isoniazid
• Antifungals - Griseofulvin and voriconazole
• Anticonvulsants - Valproate, ethosuximide, carbamazepine, and hydantoins
• Hormonal therapy - Leuprolide acetate
• Antihypertensives - Hydralazine, methyldopa, and captopril
• Anti-inflammatories - Penicillamine and sulfasalazine(another SULFA drug)
• Antipsychotics - Chlorpromazine
• Cholesterol-lowering agents - Lovastatin, simvastatin, and gemfibrozil
• Biologics - Interleukins (eg, interleukin 2), interferons (eg, alfa, beta, gamma), and tumor necrosis factor (TNF) inhibitors (eg, TNF-alpha)
• Inhalers - Tiotropium bromide inhaler
• Other drug categories - Ophthalmic timolol

Other causes may induce drug-induced lupus erythematosus in certain individuals for no apparent reason, such as sensitivity to the following:
• Insecticide compounds
• Certain metallic compounds
• Eosin (a fluorescent acid dye found in some lipsticks)(Not sure bout this one.....LOL....might just have to stop using lipstick!!!)

The Following User Says Thank You to Gypsylady For This Useful Post:
giamarie12 (12-29-2011)
Old 09-06-2009, 06:14 PM   #6
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heidiclouser HB User
Re: Any difference with Brand Plaquenil or Generic

each generic has different "fillers". It is the fillers that cause the allergic reaction. there are many different pharmacy changes them every now and then. i have had a reaction in the past. so you might want to find one that works and then stick to it.

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