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Where is DHEA converted to testosterone?

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Old 08-10-2008, 10:04 AM   #1
Join Date: May 2005
Location: New York State, USA
Posts: 291
whytry HB User
Where is DHEA converted to testosterone?

Does anyone know where DHEA is converted into testosterone? Is it in the adrenals or the testes or somewhere else? The reason I ask is that I started to feel better when starting to take DHEA before on Androgel. If the conversion is in the testes then them shutting down from TRT would also prevent the conversion of DHEA to T and make DHEA less effective.

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Old 08-10-2008, 11:46 AM   #2
Join Date: Dec 2007
Location: New Mexico, USA
Posts: 460
LALOV929 HB User
Re: Where is DHEA converted to testosterone?

DHEA is not directly converted to testosterone, but rather proceeds
via the intermediate androstenedione. The conversion from DHEA
into androstenedione is governed by ACTH in the adrenals and
production of gonadal androstenedione is under the control of
gonadaltropins. I don't know what the proportions are. But it
seems that some conversion takes place in the adrenals and some
(probably most) in the gonads. Can't seem to find a detailed
description of the location of the conversion.

Old 08-10-2008, 12:16 PM   #3
Join Date: May 2005
Location: New York State, USA
Posts: 291
whytry HB User
Re: Where is DHEA converted to testosterone?

Yeah, I searched the web for almost an hour and couldn't find an answer. Thanks for the information.

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