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    Old 04-04-2008, 02:14 PM   #1
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    Rebif and liver problems

    My sister takes Rebif and has for a few years now. However, she can only inject half of the solution as she feels ill when she takes the full dose. Not only that but it causes problems with her blood/liver tests. Is there any way to make it more tolerable?

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    Old 04-04-2008, 02:30 PM   #2
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    Re: Rebif and liver problems

    If she is having such difficulty, she should consult her doctor to have her meds changed. The liver is the blood filter for the body; therefore, meds will always pass through the liver and can cause problems.

    Old 04-06-2008, 01:12 PM   #3
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    Re: Rebif and liver problems

    I agree w. MSNik--see an MS specialist and ask about a change of meds. I know a fair amount about the liver, and on Rebif my enzymes went dangerously high. They made me quit all meds for a couple of months, then wanted to try Avonex. But I'd been reading the journals (I have docor friends), and now they think Avonex may be as toxic to the liver as Rebif. So I opted for Copaxzone, which I tolerate well. Not due for another MRI til the fall, so who knows if it's doing any good?

    Old 04-06-2008, 02:41 PM   #4
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    Re: Rebif and liver problems

    Actually it was JayHawk, and not me who suggested talking to her doctor about changing meds, but thats okay- I agree.

    Rebif is a drug which builds up in the blood stream and if your sister is having trouble tolerating it, it might not be for her; however, with that said, having an issue with getting used to the side effects, is NOT necessarily related to liver problems....if her blood work is showing problems with liver enzymes- then YES she needs to consider taking another drug, probably copaxone....however, if its simply a matter of getting used to the flu like side effects, this goes away after 3 or 4 months on the drug, once the body wont go away though if she isnt doing it right, or using the entire amount...the drug is originally titrated, so that you start out with only a quarter of the drug, then go to half strength and eventually get to full strength, which is 44 mcgs.

    For the record, Avonex and Rebif are the identical drug, simply given differently...while Avonex is once a week, intra muscularly, Rebif was introduced to be 3 times a week, subcutaneously so that the blood levels would remain more consistent....if one is not working due to liver problems, it wouldnt be recommended to switch to the other. Copaxone, is a completely different drug and is a better bet if one of the first two failed.
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