It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....

Pain Management Message Board

Opiate Tolerance

Post New Thread   Closed Thread
LinkBack Thread Tools Search this Thread
Old 10-23-2003, 10:51 PM   #1
Join Date: Oct 2003
Location: Wilkes-barre, Pa USA
Posts: 1
neuromind HB User
Question Opiate Tolerance

Anyone know of any substances that lower opiate tolerance. I went from 2 reg strength vicodin , 2months later im up to oxy 40mg 3x daily.

Sponsors Lightbulb
Old 10-24-2003, 01:56 AM   #2
Junior Member
Join Date: Oct 2003
Location: CA
Posts: 24
kmail HB User

Not that my response can help, but I think tolerance may be related to past use of drugs and/or amounts of over the counter meds taken prior.

Even so, it has taken 6 years for my husband to go from Vicodin up to 200mg oxycontin/day.

Ask your doctor, and do a search of "drug interaction oxycontin." There is a website I used to check (when my Mom was on all kinds of meds) to see if new drugs she was given would interact with her current meds. I will look at the papers I got with hubby's oxy to see if there are things you should avoid. If I find anything I will post it.

Strange, though, most docs are afraid to prescribe such strong meds, and yours happily prescribed Oxy? It took us probably nearly a year to get Oxy from Kaiser dr. Can you tell me what type of pain you suffer from?

Old 10-24-2003, 09:23 AM   #3
Join Date: Aug 2003
Location: Oh
Posts: 307
dwpavlik HB User

I have tried to lower my tolerance by taking less of my meds. In the winter time I have to use the highest strength of my meds. I use Oxys. It is prescribes to use 80mg twice daily. In the summer I can use 4 tablets every 6 hours. Or even only take 3 per day at 8 hour intervals. But in the winter I need the -mg dose and I need to take a fifth tablet per day to not get the withdrawal from when the 80's ware off in the early morning. But When I am able, like Summer time, I simply take less of the meds and lower the tolerance that way.

Old 10-24-2003, 03:47 PM   #4
Join Date: Jun 2003
Location: Ottawa,Ontario,Canada
Posts: 53

I use to take alot i mean alot of over the counter pain stuff and they never worked but i kept taking more and more to hopefully get relief,now that i know whats wrong with me i get percribed 80mgs of oxycontin twice a day and 10mgs of oxy ir when needed.and it still does not really help with my pain but better then the lower doses i have recentley been on.Best to talk with your Dr about it and maybe he/she will have a good solution.

Old 10-24-2003, 10:04 PM   #5
Join Date: Aug 2003
Location: USA
Posts: 28
PoloBailey HB User

Just try to do your best and keep a positive attitude. It is very hard NOT to increase your meds when you are hurting. But just keep in mind that in the long run it will be much better for you. I always thought that if I kept on increasing my med's, years later I would be taking so much of them I would be sicker and sicker because of so much medication in my system. If you can just keep them as low as possible for as long as possible, it will give you room later on in life to increase it later on.

GOOD LUCK !!!!!!!!!!!!!!!!!

Old 10-24-2003, 11:43 PM   #6
Join Date: Oct 2003
Location: Colorado
Posts: 9
4mykids HB User

I don't have an answer to your quesion, but kmail, I have kaiser too and it seems like they are even harder to deal with than other doctors. At least that's been my experience. It took 1 1/2 years to convince them to do an MRI, when I know my old doctor with Aetna would've ordered it in a heartbeat. Just my two cents.

Old 10-25-2003, 05:26 PM   #7
Senior Veteran
Join Date: Jun 2003
Posts: 3,522
Shoreline HB UserShoreline HB UserShoreline HB UserShoreline HB UserShoreline HB UserShoreline HB UserShoreline HB UserShoreline HB UserShoreline HB UserShoreline HB UserShoreline HB User

Hi NM, You should talk toyour doc about using dextromathorphan. It's now available n a gel cap of pure DM called Dexalone. Dex is a NMDA receptor blocker whci is believed to increase ones tolerance to pain and decrease ones tolerance to meds. Meds that bind to this site rather than block can cause Hyperalgesia=increased pain.

Methadone has some NMDA blocking ability, that is why it's suposed to work better on nerve pain and people develop slow tolerance to this med. Levo-phanol is anoth mild NMDA blocking agent. Giving other opiates the ability that meth has is in the process of clinical trials where LA morphine products are being deveveoped with dex.

When Hydrocodone is compounded into a pure long acting version without apap, dex is used to prolong duration and increase efficacy. Talk to your doc about dex, plain old cougn syrup. Compounding hydro and dex capsules requires a special compounding pharmacist and are certainly more expensive than generic vicoden off the shelf.
If you have muscle spasm, controlling the spasm would be an adjunt med and increase opiates effects. Why are you taking hydro if I might ask? It's hard to give blanket advice since all pain doesn't respond the same way to ceratin meds.
Good luck, Shore

Old 10-25-2003, 06:13 PM   #8
Join Date: May 2002
Location: van nuys, ca, us
Posts: 169
igy76 HB User

Hi Shoreline,

Well what you just said was news to me, about that drug I mean. So, to get it clear, dextromathorphan is what, an active ingredient in cough syrup (i.e. - Nyquil)? Okay then, could you answer me this: obviously no matter what we're on, EVERYBODY here would love to be able to have a slower tolerance to their meds, not to mention higher for pain. And I'm even on Methadone, which like you know, has that slower rate. But could even I go out and by cough syrup, take a couple doses during the day and have it stretch out my tolerance even more? Does it work that way, or am I being naive and just wishful thinking? (or like I said, no matter what med you're on, you'd maybe want to take that to increase your tolerance).

But of course, maybe I've got it all wrong, in the same way that you can't just go and pick a poppy plant, devour it on the spot and expect to get high from it or something. Thanks and take care

Old 10-26-2003, 06:26 AM   #9
Senior Veteran
Join Date: Jun 2003
Posts: 3,522
Shoreline HB UserShoreline HB UserShoreline HB UserShoreline HB UserShoreline HB UserShoreline HB UserShoreline HB UserShoreline HB UserShoreline HB UserShoreline HB UserShoreline HB User

Adding Dex "yes The active ingredient in cough syrup" to meth isn't really going to give it a property it doesn't already have. That is blocking the NMDA receptor. It may increase meths blocking ability so it somewhat depends of your dose of methadone.

My dose is rather high so adding 90 mgs of dex didn't really do anything the meth wasn't already doing. However if your dose is relatively low, say 30-40 mgs a day then a boost of pure dex 30mgs TID may help with tolerance and pain perception. Dexalone is a 30mg capsule of pure Dex. TID is the standard dosing instructions. It's not cheap though so you would have to have a noticeable improvement to make it worthwhile.

Ketamine is also a strong NMDA receptor blocker but I don't think your doc is going to want you to take street special K to boost the effectiveness of your opiates. Ketamine is an animal tranquilizer that happens to block the NMDA receptor too. It's also a popular designer street drug like ecstasy and GBA.
Perhaps in the future small amounts of Ketamine will be added to LA meds to give them the same NMDA blocking ability.

They are making progress in understanding all the receptors involved in pain management and perception. Unfortunately it's against the TOS to post or cut and paste such articles.

Ketamine is occasionally used on humans to induce a coma to break the cycle of chronic daily migraines but requires use of a vent when you induce a coma.

The best results have been found when adding dex to morphine. Many of the new LA morphine products in clinical trials are being developed with dex.

Using cough syrup that's not pure dex is going to add other meds into the mix that may not be safe, thus the need for a pure dex capsule "Dexalone"

Nyquil is going to add more than just dex, the alcohol alone is going to have an impact on every med you presently take plus the antihistamine will have some impact on your meds.

Talk to your doctor about adding Dexalone to your present meds, other interactions have to be considered before just adding an OTC cough syrup to the mix.

I would post a link about Dex and the NMDA receptor but after my week of reflection
LOL I find it unfortunate that people aren't able to actually help more than just offering a shoulder to lean on.

Talk with your doc about DEX, If your doc actually has an interest in the science of PM he will be up to date on what DEX can do for you and possibly suggest reading material without being punished.

MY ability to post outweighs my desire to back what I'm suggesting with actual aricles or links.
I really am sorry I can't be more help, Shore

Do a search for Dex and opiate interactions.
Or do some research on the NMDA receptor or Ketamine and the NMDA receptor.

[This message has been edited by Shoreline (edited 10-26-2003).]

Closed Thread

Similar Threads
Thread Thread Starter Board Replies Last Post
oxycodone ir opiate tolerance doses Troyguy Pain Management 1 01-03-2010 07:53 PM
Executor-? about fentanyl patch/"opiate tolerant" tattoogirl Pain Management 2 09-21-2009 01:43 PM
"opiate induced pain syndrome" and pain meds questions.... Melnwest Pain Management 12 09-15-2009 04:47 AM
Any insight?? Opiate tolerant? What comes after ESI's and trigger points? skych Pain Management 4 10-12-2007 08:02 AM
Amantadine for opiate tol. reversal mrcool812 Pain Management 9 01-15-2007 05:31 AM
opiate receptors and metabilism question milimoki Pain Management 5 07-11-2006 08:58 AM
Dr. said an Opiate is an Opiate catnap Pain Management 12 11-18-2005 11:48 PM
Anyone who's stuggling with opiate addiction, "PLEASE READ" nluv Addiction & Recovery 8 10-13-2005 02:15 PM
Cleaning the Opiate Receptors curiousdms Addiction & Recovery 1 01-26-2005 02:43 AM
Can someone explain what opiate niave means mommy2scl Pain Management 6 12-22-2004 05:41 AM

Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is Off
HTML code is Off
Trackbacks are Off
Pingbacks are Off
Refbacks are Off

Sign Up Today!

Ask our community of thousands of members your health questions, and learn from others experiences. Join the conversation!

I want my free account

All times are GMT -7. The time now is 02:20 AM.

Site owned and operated by HealthBoards.comô
© 1998-2018 HealthBoards.comô All rights reserved.
Do not copy or redistribute in any form!