It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....

Panic Disorders Message Board

  • serzone/nefazodone and liver failure

  • Post New Thread   Closed Thread
    Thread Tools Search this Thread
    Old 05-20-2004, 12:07 PM   #1
    Senior Veteran
    Join Date: Feb 2003
    Location: melbourne, vic, aust
    Posts: 7,368
    hry33 HB Userhry33 HB User
    serzone/nefazodone and liver failure

    Maker to Pull Antidepressant Off Market-AP News

    By LAURAN NEERGAARD, AP Medical Writer

    WASHINGTON - The maker of Serzone will pull the controversial antidepressant off the U.S. market next month, blaming a decline in sales rather than concern about a risk of liver failure.

    The end to U.S. sales comes after Serzone was pulled off the market in many other countries, and as maker Bristol-Myers Squibb was under mounting pressure from lawsuits. Serzone has been linked to dozens of cases of liver failure and injury, including at least 20 deaths.

    A Bristol-Myers spokesman confirmed the decision in an interview Wednesday, a day after the company notified wholesalers that distribution would end June 14.

    The end to sales "is long overdue," said Dr. Sidney Wolfe of the consumer group Public Citizen. "None of the other antidepressants causes liver damage like this."

    Wolfe last spring sued the Food and Drug Administration (news - web sites) seeking to force a ban on Serzone. That suit will proceed in an effort to also end sales of generic versions of Serzone, called nefazodone, Wolfe said.

    An Alabama attorney said he would ask the company and the FDA to go a step further and recall Serzone, saying that patients shouldn't continue to buy and use the pills between now and June 14.

    "I really think that's a ploy to take the heat off," said Jere Beasley, an attorney in Montgomery, Ala., representing 30 families in Serzone lawsuits. "It's not going to solve the problem."

    Bristol-Myers spokesman Rob Hutchison said that the decision had nothing to do with safety questions and that the company would continue to vigorously defend the pending lawsuits.

    "We still believe, and I believe the FDA does, too, as well as physicians, that nefazodone is an important therapeutic option for patients with depression," Hutchison said.

    Instead, the company is discontinuing Serzone because of rapidly declining sales after generic competitors hit the market last year, he said. "Our market share is very small."

    Sales of 16 other very old products also will cease, he added.

    Bristol-Myers ended Serzone sales in Europe over a year ago, citing declining sales. Canadian regulators banned the drug last fall because of the liver risk. Sales in Australia and New Zealand are about to end, too.

    The FDA has received reports of at least 55 cases of liver failure, including 20 deaths, and another 39 cases of less severe liver injury since Serzone began selling in 1994. In 2002, the FDA added to Serzone's label its strongest type of warning about the liver risk, maintaining that liver toxicity is a rare risk adequately managed by warning patients.

    But Wolfe notes that the World Health Organization (news - web sites) and Canadian regulators last year compared a number of popular antidepressants and found only Serzone was linked to an increased risk of serious liver injury.

    Canadian authorities said they banned the drug because there was no way to predict which patients would be at risk for liver failure. Routine liver tests haven't reduced that risk, they said.

    serzone is an antidepressant, sometimes used for anxiety and panic attacks

    Sponsors Lightbulb
    Old 05-22-2004, 07:37 PM   #2
    Senior Member
    Join Date: Mar 2004
    Location: california
    Posts: 120
    panickyjess HB User
    Re: serzone/nefazodone and liver failure

    i have been on serzone for over 3 years and never got tested for liver stuff till i was taking it for 2 years...but i think im still on it whats gonna happen when they stop selling i just stop taking it...does anyone know?


    Closed Thread

    Related Topics
    Thread Thread Starter Board Replies Last Post
    Serzone atrooterisu Depression 4 11-17-2007 08:21 PM
    Anyone ever take Serzone? jodianne Anxiety 6 03-16-2007 02:05 PM
    Generic form of Serzone side effects Iloveturtles Mental Health 1 02-24-2007 12:13 AM
    Experiences with Serzone (Nefazodone)? Hotpaws Depression 7 08-23-2006 01:57 PM
    Serzone withdrawal - input and help requested Kiminca Depression 0 09-15-2004 10:07 PM
    Serzone? BrianD Panic Disorders 6 04-18-2003 06:24 AM
    Staring off into space??? Vision/Memory problems and Serzone? Cam94Z28 Eye & Vision 0 12-16-2002 04:20 PM

    Thread Tools Search this Thread
    Search this Thread:

    Advanced Search

    Posting Rules
    You may not post new threads
    You may not post replies
    You may not post attachments
    You may not edit your posts

    BB code is On
    Smilies are On
    [IMG] code is Off
    HTML code is Off
    Trackbacks are Off
    Pingbacks are Off
    Refbacks are Off

    Sign Up Today!

    Ask our community of thousands of members your health questions, and learn from others experiences. Join the conversation!

    I want my free account

    All times are GMT -7. The time now is 10:01 PM.

    2019 MH Sub I, LLC dba Internet Brands. All rights reserved.
    Do not copy or redistribute in any form!