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    Old 08-24-2008, 01:35 PM   #1
    oldcow
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    Smile I am back

    Hi,
    I have not poster here for 3 to 4 years. I am still "kicking" with 25 plus years
    of delightful PD !!
    Where are all the "old timers" ??
    take care
    John g (oldcow).
    (((

     
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    Old 08-24-2008, 03:18 PM   #2
    glama9
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    Re: I am back

    That is the kind of news we want to hear! What are
    you taking for this devastating scurge? Any recommendations?

     
    Old 08-24-2008, 06:01 PM   #3
    oldcow
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    serotonin syndrome

    Azilect (Rasagiline) is a once-daily product and one of the few treatment
    options in the U.S. indicated for all stages of PD. It is an irrerversible monoamiine oxidase (MAO) type B inhibitor.
    A potentially life-threatening adverse drug reaction that may occure following it's use and is called Serotonin syndrome, or serotonin toxicity, or "cheese reaction," and is due to excessive amounts of serotonin in the CNS. Although, Azilect generally does not cause such reactions in therapeutic
    PD doses. It is recommended that patients avoid foods (sharp cheeses) and
    red wines containing amines such as tyramine. Also, it is not recommended
    to be taken with Selective Serotonin Reuptake Inhibitors (SSRI,s), tricyclic
    antidepressants, amphetamines, cocaine, demerol (meperidine) and the
    list goes on and on.
    By inhibiting MAO-B, Azilect prevents the metabolism of dopamine, thereby
    increasing the concentration in the synapse.
    Another enzyme (cathechol-o-mthyltransferase [COMP])that metabolizes the precursor (levodopa) to dopamine is entacapone (Comtan).

    John g
    )))

     
    Old 08-24-2008, 06:29 PM   #4
    oldcow
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    Smile Hi glama9

    The forum is a little confusing.
    Meds I take are Stalevo 150, 1 every 4 hours; generic Sinemet 25/100,
    1/2 tab 3 times a day; generic Zoloft 50 mg daily.
    Also, I had a bilateral DBS surgery 5 years ago.
    I still can walk, drive a car and take care of myself.
    I no longer run for exercise.
    John g
    )))

     
    Old 08-25-2008, 06:21 AM   #5
    glama9
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    Re: serotonin syndrome

    Dear oldcow,
    Thank you for your informative reply. Do you take Azilect and have you found it helpful?

     
    Old 08-25-2008, 12:19 PM   #6
    oldcow
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    Re: serotonin syndrome

    Hi glama9,
    No i don't take azilect, but I am thinking about it. I currently am taking Zoloft
    (antidepressant) 50 mg per day. Teva, the mft. of Azilect states that the selectivity of
    Azilect at inhibiting MAO-B in humans has not been sufficiently established . Therefor, it's
    use is restricted with Zoloft. In other words there is a drug-drug interaction between the two. [ not stated very clearly ]. I thing its ok but I will have to run it by my movement specialist.
    Take care.
    John g

     
    Old 08-25-2008, 04:10 PM   #7
    glama9
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    Re: I am back

    Teva is presenting the results of the Adagio trials tomorrow in Europe regarding the protective benefits of taking Azilect. Here's hoping for all of us!

     
    Old 09-02-2008, 08:07 PM   #8
    sunshine221
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    Re: I am back

    I've taken Azilect since Jan - at first I didn't think it was doing anything and I still can't be certain - but a hardly ever have a tremor anymore - besides a gait issue which is unlike a PD gait my only PD symtpom is lack of arm swing. I take .5mg of azilect 1/d and 1mg of requip 3x/d

     
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