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  • PCOS & Endometerosis- Metformin & Anti-androgen meds???

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    Old 05-23-2010, 06:34 PM   #1
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    PCOS & Endometerosis- Metformin & Anti-androgen meds???

    Hi all.. I am still sort of new to this website, I was hoping to get some advice/support. I am 29 yrs old and married for 6 years. My husband is as frustrated as I am.

    As a child (6 yrs old), I was diagnosed with precocious adrenarche and ovarian cysts. Since that time I have battled (I do mean battled too) with ovarian cysts, rupturing cysts, crazy periods and endometriosis. I have gained a lot of weight over the last couple of years, about 50 lbs. Until I was 23 I was 115 lbs.

    I have tried all of the treatments for the endo... lap, bc pills, lupron etc and have one more dr appt with Dr McGuirk who is supposed to be great (fingers crossed) tomorrow. My obgyn wants to do a full hysterectomy and I have finally wrapped my head around it and accepted it. But now this specialist thinks she can help... I can't help but feel skeptical. I have been dealing with this for so long and no one has ever been able to help. The last treatment of a new BC pill caused such bad migraines I ended up in the ER with drs thinking I had meningitis, so I had 2 drs attempt a lumbar puncture 4 times for an hour before they got fluid. So I am about out of hope for a normal life.

    My endocrinologist is testing all my hormones and is starting me on an anti-androgen med and metformin for the PCOS. Does any one else take these meds? If so what are your thoughts and how have you responded to the treatment?

    Thank you for any and all help/advice!!!!!!

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    Old 05-24-2010, 07:02 AM   #2
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    Re: PCOS & Endometerosis- Metformin & Anti-androgen meds???


    I don't understand. Are you being put on both the Metformin AND another anti-androgenic med (like Spironolactone perhaps ?) .. or just the Metformin ?

    Metformin is usually a second line treatment for PCOS after the birth control pill. Quite obviously if you are suffering from migraines, the pill is definitely not for you.

    This drug is definitely the second line treatment if your goal is to regularize your periods and help to control your weight. However, I hope that your doctor has tested you to make sure that you are a good candidate for this. She should have checked your creatinine levels (ie. to do with kidney function). Also, I assume that you have definitely been diagnosed with PCOS and that you have higher than normal androgen circulation in your blood, right ? There are two types of testosterone to check for: bound and free. The free testosterone is the one that is active so it is the one to look out for.

    I personally was put on Spironolactone for a while when I was a kid because I have hirsutism (ie. lots of facial hair). It did absolutely nothing for me and I was eventually taken off of it. At the age of 20 I went on the pill for birth control reasons and the hair problem was not as prominent. At the age of 40 I went off the pill as it began to give me problems. Now at the age of 43 I am noticing the hair problem starting to come back but I have decided to control it with electrolysis or some other hair removal technique rather than messing with something systemic. I was never diagnosed with PCOS but I did have slightly elevated testosterone levels in my blood as a child and adolescent. With 20 years of pill use, my bound testosterone is very high and my free testosterone is very low. The pill is known to bind testosterone so I suspect that 20 years of use caused this. I also had screwed up periods as an adolescent but this obviously regularized when I went on the pill (fortunately) and now that I am off of it, my periods are still regular (touch wood). I have never wanted children so fortunately for me, fertility was never an issue. I did have to have a large ovarian cyst removed with surgery (lap) last year.

    Just make sure that you are indeed a good candidate for this drug and really see if it is necessary to be put on both drugs if they are recommending both.

    Hopefully someone who has tried this drug will chime in but I just thought I would put this in, in case it can be of some help to you.

    All the best,


    Old 06-22-2010, 08:20 AM   #3
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    Re: PCOS & Endometerosis- Metformin & Anti-androgen meds???

    I wish someone had told me there were options out there when I was diagnosed. I have known I have had PCOS for a very long time, probably since I was in my teens. I was not "truly" diagnosed up until about five or six years ago, I am now almost 41. NO ONE seemed to know or care what was going on with me. I had to research and find out everything I now know on my own. I do have a wonderful dr now that specializes in PCOS but it is now too late (unless I want to try and have a baby when I am pushing 50). As much as that would be a blessing, I have reserved myself to being happy to just be able to control the symptoms I have. The anxiety and mood swings are a nightmare. To make it worse my poor wonderful husband of 15 years is getting the brunt of it all. Thank goodness he is a very loving and supportive man. I work 40-50 hours a week in addition to attending college for an additional 10 hours + each week so I have a pretty full plate. I just want to for once be able to sleep through the night and not wake up drenched in sweat or feel like bursting into tears every time I turn around. Does ANYONE have any suggestions?

    Oh, not to mention the weight gain. Due to the gradual weight gain about 10 years ago and excessive weight gain within the last three or four, I am now having other health issues like high cholesterol and over 300 triglycerides. I need help and I need it now. I have changed my diet (eat nothing but cardboard and water practically) but nothing is working. Along with everything else this new issue has got me scared and extremely which is adding to my frustration and anxiety.

    Last edited by seals3026; 06-22-2010 at 08:26 AM. Reason: forgot something

    Old 07-09-2010, 08:27 AM   #4
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    Re: PCOS & Endometerosis- Metformin & Anti-androgen meds???

    By reading your contributions i've realized that I'm not the only one suffering like this. Your stories are so similar to mine. I was also 115lbs at 23, I'm 28 now and I'm 170! I've been married for 4 years, no kids because of PCOS which in my case seems to be so hard to get under control.
    I have been prescribed the Metformin which has sometimes helped with control my irregular periods but the side effects are so bad sometimes I find it hard to keep up with it.
    My cholesterol has also been high with triglycerides in the 300s but my nutritionist thinks that is a result of my thyroid issue, I also have hypothyroidism.
    I think when I don't take the Metformin like I should I develop serious issues with my cycle. I've been having my period for 135 days now, my gyn did a biopsy to make sure there are no abnormalities but recommended I restart the Met to help my ovaries. I'm also on Novynette bc. I think if you can tolerate the Met it'll help in the long run. Hang in there.

    Old 11-24-2010, 12:10 AM   #5
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    Wink Re: PCOS & Endometerosis- Metformin & Anti-androgen meds???

    i tried spirolactone and it swell me up something good but i can tell you that it is not to late to have a kid if that is what you want metformin is good at regulating your cycles and if not ivf is the way to go the weight issue you can achieve by cutting some of the refined carbs out. dont stop eating cause this further slows down your metabolism. food is the way to keep the metabolism burning you just have to eat the right foods and the weight will come off good luck to you

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