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Postpartum Depression (PPD) Message Board

postpartum depression--want to go off zoloft

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Old 12-30-2005, 07:02 PM   #1
Join Date: Dec 2005
Posts: 3
momof2girlz HB User
postpartum depression--want to go off zoloft

Hello--I'm new to posting.. I am a 26 year old mother of 2 (2yrs & 7mos.)--beautiful girls. I suffered from Postpartum depression with my first child, but refused medication---and regretted it--after the birth of my second, I went on Zoloft--100mg. I would like to go off of it, but my husband doesn/t think it is a good idea, I am also nursing and worried about my daughter and any withdrawl. I am very physically active (ran a 1/2 Marathon when the baby was 5 mos.) and am hoping that running will help me cope with any adverse reactions.. I am looking for anyone with any insight on my situation. My Doc and Lactation consultant say that Zoloft does not have any withdrawl problems--any advice would be appreciated!

Last edited by momof2girlz; 12-30-2005 at 07:04 PM.

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Old 01-01-2006, 11:26 AM   #2
Join Date: Dec 2005
Posts: 300
gort HB User
Re: postpartum depression--want to go off zoloft

Here's something I came across that you could discuss with your doctor. It may lessen the withdrawal effects.

Omega-3's as Antidepressant in Pregnancy:
A Case Report

(letter) **** CC, Huang SY, Shen WW, Su KP Omega-3 fatty acids for depression in pregnancy. Amer. Journal Psychiatry. 2003 Feb;160(2):385

This is the story of a woman in China who had a previous depression during pregnancy, lasting 9 months after the pregnancy, and finally then recovering -- without medication treatment. Then she had two more episodes of depression while not pregnant, which responded to paroxetine (Paxil in the U.S.).

But when she became depressed during another pregnancy, she did not want to take medications for fear that they might harm her baby. So, these doctors offered her the Omega-3 option, as they had been studying this approach in other patients (see the Omega-3 table: Su, 2003).

The dose was 4 g of ethyl eicosapentaenoic acid (EPA) and 2 g of docosahexanoic acid (DHA) per day.

She did not improve until the 4th week of this treatment, when her depression score (HAM-D) went from 29 to 18. By week 6 her score was 10, and she reached "remission" -- a depression score of 7 -- by the 10th week.

Was it really the omega-3's that did this? The doctors concluded yes:

Since the patient received regular follow-up for 6 weeks before treatment with omega-3 polyunsaturated fatty acids, it is unlikely that the remarkable improvement was due to the clinical attention of regular visits. Because the patient had a depressive episode during her first pregnancy and after childbirth, we do not think that she had a spontaneous remission from this episode.

In their conclusion, the doctors wonder whether the developing fetus might actually take omega-3's from mother, lowering her levels, and making her more susceptible to depression (numbers in parentheses are in their letter's references):

Reduced maternal DHA status after the second trimester (4) is associated with a high demand from the developing fetus for the rapid formation of its brain. Empirical studies of polyunsaturated fatty acids in the tissues (5), data from epidemiologic surveys (6), and results of therapeutic trials of polyunsaturated fatty acids (1) suggest that a deficit in omega-3 polyunsaturated fatty acids might cause major depressive disorder (7, 8). Supplementation with omega-3 polyunsaturated fatty acids is thought to have protective effects for pregnancy outcome in high-risk pregnancy (2).

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