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    Old 02-08-2005, 11:30 AM   #1
    bear_760
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    Quad Screen Results. please read

    Hi, I just got my results back for the quad screening and 1 result came back positive for down syndrome. From what I understand, the quad screen is a ratio of the chances a baby will be born with down syndrome. For me at my age range (33) my ratio should be 1 in 296 babies but yesterday i found out it's 1 in 131. My doctor was very reassuring that this does not mean my baby has downs but that further testing is an option. So my husband and I have an ultrasound II tomorrow that will give me further info on the baby and of course the amnio would be offered after, if it's something we wanted to do. I just wanted to know if any other moms-to-be had this happen to them. I'm 4 months right now and like my doc said, she has seen this ratio come up many times and babies are born healthy. But i'm still so scared and nervous.. any responses will be appreciated.

     
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    Old 02-08-2005, 01:12 PM   #2
    sumi
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    Re: Quad Screen Results. please read

    Hello,
    I am sure you must be so concerned which is completely understandable. My sister and best friend had the same thing happen to them. In my sisters case they told her so many different things and she had so many test done but ended up having a little girl with Marfan Syndrome which is completely genetic (from her husbands side) and her little girl now three ver smart and can speak two languages. My best friend had the same thing happen to her which was very difficult for her and her husband as they had to make choices no parent wants to even think about. Their choice was to keep their little angel and not to even go through any other testing. Well, their little girl was born as healthy as any other baby and has no sign of downs syndrome.
    I don't think you should stress yourself out as it's not good for the baby or for you. Wait until tomorrow and remember they CAN be wrong.
    Good luck my dear, you will be in my prayers. Keep us posted.

     
    Old 02-08-2005, 01:23 PM   #3
    jmcummins3
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    Re: Quad Screen Results. please read

    I have heard the same thing that it's just a screening test and there is a high rate of false positives from the test. I know it's hard, but try not to worry too much right now.

     
    Old 02-08-2005, 01:50 PM   #4
    nyxin
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    Re: Quad Screen Results. please read

    there have been several women on here that have had a positive result. the thing that you have to look at is that is that it is not an exact science. as it was explained to me, at a certain point in the pregnancy the blood is drawn to measure different levels. it usually is most accurate around that time (i think 14-15 weeks or so?) anyway, picture a scale that looks like this |__________| so in that little space is "normal" well, if you fall even slightly to one side or the other, a flag goes up and you are marked for a potential problem. the thing is though, that within that space is a pretty significant difference from the far right to the far left, but there has to be a gauge somewhere right? so a beginning and an ending of what is considered normal for that time frame was established. meaning you can be way closer to the start of normal and still be flagged than on the ending side of normal and not be. does that make sense? you would be amazed at how many people actually do fall outside those silly little boundries. this could be because of a not an exact right gestational age, or genetic hormone release- not indicitive of downs at all. many women are NOT getting these tests because of the extra worry. i did have the test done because there is other tubal problems in my DH's family, but like i said it is not an exact science. i mean, 1 in 131 arn't even as good as lottery odds!
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    Old 02-08-2005, 02:09 PM   #5
    beanie_1122
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    Re: Quad Screen Results. please read

    The same thing happened to my cousin it came back positive they put her thru all kinds of testing and when she delivered her daughter she was completly healthy no health problems what so ever!!! If you don't plan to end the pregnancy with the further testing results I don't see any sense of putting yourself thru the torture!! The amnio test caz be dangerous and cause harm to your unborn child and in my opinion its not even worth taking in this type of situation! Good Luck!

     
    Old 02-08-2005, 03:38 PM   #6
    hillaryb
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    Re: Quad Screen Results. please read

    I actually opted out of those tests. I was low-risk for having a down's baby and my doc and the nurses said that the false positive rate was so high, it wasnt worth the stress. They actually had a nurse there that had a false positive. The point they made was that the testing is inaccurate so what is the point of having it?

     
    Old 02-08-2005, 08:41 PM   #7
    cattieos
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    Re: Quad Screen Results. please read

    I have a higher risk for having a baby with spinal problems, which the test can also detect, but I opted out too, because of the high false postives, and because I was going to keep the baby regardless. I just didn't see the need for extra worry! I am sure it is impossible for you not to worry about it, but just try not to, i will keep you and your baby in my prayers, and even with the worst case scenario, i have seen people with downs live full lives. Good luck with your ultrasound!

     
    Old 02-09-2005, 03:36 AM   #8
    Kiera1595
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    Re: Quad Screen Results. please read

    I tested positive for Downs with my baby...there is a 1 in 270 chance for us. We went for our level II ultrasound where they take a very close look at things. The tech and the doctor agreed that they saw no markers for downs. Which doesn't mean that we are out of the dark, but it's hopeful. We then (at the same visit) talked to a genetic specialist. We don't have any traits on either side of the family which was of any concern, but we had to decided to do the amnio or not. That is the only way you will know for sure! The national average of something happening to your baby due to the amnio is 1 in 200. The risk of miscarriage is about 1 in 400. We decided to pass. But they also told us that we didn't HAVE to do it that day. If we went home and thought about it for a few days and couldn't stand the worry, we could come back. We just thought the odds were worse of something happening with an amnio. I asked the specialist if it would become more obvious at later ultrasounds if the baby had downs and they said no.

    Now we just have to wait for delivery to find out for sure. I was really spooked until the ultrasound. Then I was somewhat spooked for the next two weeks. It slowly starts to fade I don't even mention it to people when they ask about the health of the baby. However I must admit that now that her due date is a few weeks away I'm starting to think about it again.

    Like others say...there is a huge rate of false positives. That's why its pretty controversial to do the test in the 1st place. Try to stay positive. See what they say today. Let us know what they say and if you need a buddy to talk with, I'm here!!!
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    Old 02-09-2005, 04:15 AM   #9
    ryantiques
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    Re: Quad Screen Results. please read

    Two of my sisters had positives for downs and both babies (boys) were born healthy with no signs of any genetic anomolies.

    I am now 26 weeks and at I believe 16 or 17 weeks I tested positive for Trisomy 18, I didn't get the initial ratio but was referred to a university hospital for level II US.

    I had waited for the optimal time which they said was 18-20 weeks for the US and at 19 weeks went in. Because of previous complication with pregnancies and disability due to abdominal muscle tumors the level II US was not what I had hoped for. I had trouble hearing the babies heartbeat with doppler because of mesh, adhesions and scar tissue. The level two US was also ineffective at visualizing the soft tissue structures and things they needed to see so I opted for the amnio.

    I started before the US with a ration of 1:37 and after the US because of the problems viewing the OB changed it to 1:20 in addition to what measurments the baby was measuring small in approximately the 13th percentile.

    I'll tell you the two weeks waiting for the amnio results were awful. I would normally have not done it but because of the low ratio, the problems with the US's I had and my age (34) I couldn't not know as Trisomy 18 is something that I couldn't bear to live with as most babies don't survive birth or make it more than two weeks post delivery.

    You really have to weigh out all the options. Thankfully there was a positive result with the amnio and NO genetic defects were seen. I do have to have US's bi-weekly because of Hannah's size and watch her growth rate closlely but I feel that everything will be fine with her. I delivered a daughter in 1995 3 weeks early that weighed 7lbs 11oz and a son in 1999 that weighed 10lbs 1 oz.

    I hope you find the answer your looking for, for me it was essential, I just had to get some news on my babies health regardless because all the previous prenatal appts and US's told me nothing, in addition to not hearing her heartbeat like everyone else does the reassurance could only be gained by amnio.

    Best of luck to you, please do keep in mind the rate of false positives is so so high. The other thing to consider as I did because the ratio of the Trisomy 18 gene. was 1:20 and the risk of miscarrage from the amnio was closer to 1:275 I needed to know and the risk of Trisomy 18 far outweighed teh risk of misscariage.

    Take Care and God Bless
    Jessica

     
    Old 02-09-2005, 08:46 AM   #10
    hillaryb
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    Re: Quad Screen Results. please read

    Though amniocintesis is considered to be relatively safe, people DO sometimes miscarry after having one. Even with the risk being low, I dont know if it would be worth the risk. One of the reasons I didnt have testing for downs was because it wouldnt have made us have an abortion, and I didnt think it would be worth the risky tests involved with a positive result. I actually knew someone who miscarried from an amnio. She was 5 months pregnant. It may not happen often, but it does, and it is very sad.

     
    Old 02-09-2005, 05:41 PM   #11
    Jenn1204
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    Re: Quad Screen Results. please read

    I just went through this myself. I received a positive screen for DS with a 1/252 chance, I am 29 and the ratio should be around 1/1000. We went to the genetic counselor and saw a perinatologist for an Ultrasound. She did not see any soft markers indicating DS, however US is only 50% effective in picking up these markers. At that time, we decided against an amnio. We left that day feeling pretty good that everything was okay. Over the next couple of days, I just couldn't shake the feeling of the unknown for the next 5 months. I went back and had the amnio to put my mind at ease. I just wanted to be able to enjoy the rest of my pregnancy without the feeling that something could be wrong. The amnio went extremely well, we were in and out of there in 10 minutes, and I had no pain during or after the procedure. The perinatologist that performed the amnio has been in practice for 25 years and I felt very comfortable with her. I am really glad that we made this decision, and I just found out today that everything is fine, 46 chromosomes no DS.

    There definitely is a high percentage of false positives. Of all the people who get a positive screen only 3% actually have a baby with a genetic disorder.

    Good luck!

    Jen

     
    Old 02-10-2005, 11:40 AM   #12
    bear_760
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    Re: Quad Screen Results. please read

    thank you all for the comforting replies. i had my ultrasound yesterday and it went very well. they saw no markers that would suggest downs but again they said it's 50% detection. they measured the legs, the heart, made sure there was no extra skin on back of neck and there was no clench fists.. oh and she is girl!!!!!!! we are sooooo happy... so the ultrasound was very comforting and the genetic counselor said that since the ultrasound did come back great, that it would decrease my risk from 1:131 to 1:260. so i have decided against the amnio. i would be devastated if there was a miscarriage knowing that i will have this baby no matter what so i will stay positive. my husband and i are so in love with her already.. very precious!!! anyways, thanks again for all the great help..

     
    Old 02-10-2005, 07:46 PM   #13
    ryantiques
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    Re: Quad Screen Results. please read

    bear,

    so glad everything worked out. I did post a reply and just want to say that if my screen was positive for DS I would not have had the amnio however since it was the worst of the screenings and positive for trisomy 18 and such a low ratio and a problematic US I felt like I was between a rock and a hard place.

    I just don't want anyone here to think I'm a gambler when it comes to haveing an amnio.

    Anyway, best wishes, glad all turned out happy!
    Jessica

     
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