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mirapex vs requip

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Old 02-04-2008, 07:57 AM   #1
Join Date: Feb 2008
Location: Cotati, CA, USA
Posts: 1
wrohrer55 HB User
mirapex vs requip

I have been on Mirapex for the last couple of years now and have had great success with it. I have not had any of the side effects commonly reported. The effects are lessening though and my doctor has recommended Requip. I am just starting to make the transition. Although I am a little nervous about the reported side effects, I'll try anything if it works. Has anyone made that transition? I am 7 days into it and my RLS seems to be worse now than before. How long should I give it for a proper test?

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Old 02-09-2008, 08:39 PM   #2
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Join Date: Oct 2006
Location: Seattle, WA, USA
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brighama HB User
Re: mirapex vs requip

My experience (and that of most people) is that Requip is basically an inferior version of Mirapex in terms of side effects and efficacy.

So you've developed a tolerance to Mirapex? Don't give it up! Try a drug holiday. I was using 1.5mg of Mirapex daily, then weaned off of it for a week, and am back to only needing 0.25mg a day.

The question is how to do the drug holiday. I would not recommend using another dopamine agonist (like Requip) as a substitute. Your neurologist may have some ideas (benzodiazepines? Maybe a mild opiate like oxycodone for no more than a week.)

Don't give up on Mirapex!

Here is a just-published (Jan 2008) meta-analysis of all the Mirapex and Requip studies done so far:
[url] 2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pub med_RVDocSum[/url]
Summary: Mirapex is superior to Requip in terms of efficacy and fewer side effects.

Last edited by brighama; 02-10-2008 at 03:36 AM.

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