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Board: Cancer: Prostate 08-05-2020, 11:13 AM
Replies: 15
Views: 5,852
Posted By DjinTonic
Primary Treatment for High-Risk Disease

For men diagnosed with G8-10 disease facing a treatment decision, I highly recommend these recent papers. The first is a recent review article that also discusses quality of life. The second is a...
Board: Cancer: Prostate 07-22-2020, 04:55 PM
Replies: 15
Views: 4,259
Posted By DjinTonic
Re: PSA Rise

Many men have their Gleason score upgraded (or downgraded) after their biopsy. A biopsy samples a small amount if tissue and can easily miss the most serious lesion(s). The post-op Gleason score...
Board: Cancer: Prostate 06-18-2020, 12:17 PM
Replies: 13
Views: 13,364
Posted By DjinTonic
Re: Post Radical Prostatectomy

Excellent scan results! Regarding the psychology of it all, just anticipate the last day of your RT, when your cancer has been zapped away. Stay positive, take one day at a time, and let your...
Board: Cancer: Prostate 03-10-2020, 03:10 AM
Replies: 15
Views: 3,750
Posted By DjinTonic
Re: PSA Seven Years Since 2013 Radiation

Here is the study:

Three-year postoperative ultrasensitive prostate-specific antigen following open radical retropubic prostatectomy is a predictor for delayed biochemical recurrence (2011)
...
Board: Cancer: Prostate 03-08-2020, 05:07 PM
Replies: 15
Views: 3,750
Posted By DjinTonic
Re: PSA Seven Years Since 2013 Radiation

Staying on top of things has undoubtedly contributed to your successful treatment! Well done!

Djin
Board: Cancer: Prostate 03-06-2020, 06:30 AM
Replies: 44
Views: 19,465
Posted By DjinTonic
Re: Lack of Evidence That Surgery Is As Good As Radiation for Higher-Risk PC Patients

Gerald, if I were you, I'd be measuring my PSA every 3 months preferably with Labcorp's 3-decimal test, but certainly with a test that returns at least 2 decimal places. With a post-op PSA history of...
Board: Cancer: Prostate 03-04-2020, 10:18 AM
Replies: 4
Views: 2,004
Posted By DjinTonic
Information on the Labcorp <0.014 PSA test

Several Forum Brothers, here and elsewhere, have reported a Labcorp PSA result of <0.014. The < sign did not appear to be an error, but it wasn't clear what was going on. It appears this indeed was...
Board: Cancer: Prostate 03-04-2020, 06:11 AM
Replies: 25
Views: 14,937
Posted By DjinTonic
Re: Just Had 1st Meeting with my RO

Stereotactic Body Radiotherapy for Primary Prostate Cancer (2018, Review)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069023/



[Emphasis mine]

There is at least one ongoing trial, a...
Board: Cancer: Prostate 02-13-2020, 09:53 AM
Replies: 4
Views: 2,761
Posted By DjinTonic
Individual & joint effects of metformin and statins on high-risk PCa mortality

Individual and joint effects of metformin and statins on mortality among patients with high‐risk prostate cancer [2020, Full Text]

https://onlinelibrary.wiley.com/doi/full/10.1002/cam4.2862


...
Board: Cancer: Prostate 01-31-2020, 11:33 AM
Replies: 41
Views: 17,644
Posted By DjinTonic
Re: Are Club Membership Cards Mailed?

Hi Skipper. It's a good idea to have one's first biopsy slides sent to Dr. J. Epstein at J.H. for a second opinion from the top guru of prostate pathology. It's not that expensive.

You biopsy...
Board: Cancer: Prostate 01-22-2020, 05:16 PM
Replies: 24
Views: 2,637
Posted By DjinTonic
Re: Psa prostrate Levels

My understanding is that the first step after any unexpectedly large PSA increase is a repeat test, to rule out lab error. Often sufficient blood is taken that a repeat test can be run simply by...
Board: Cancer: Prostate 01-22-2020, 11:49 AM
Replies: 17
Views: 6,871
Posted By DjinTonic
Re: Choosing between conventional and hypofractionated RT

Yes, that statement is one of the ASTRO statements quoted in the Decision Aid; in fact, it continues...



So the patient can see one example of what "small" means in terms of the increased risk,...
Board: Cancer: Prostate 01-17-2020, 09:35 AM
Replies: 16
Views: 4,193
Posted By DjinTonic
Re: Some Pre-Biopsy Questions

A nodule (at the prostate apex) on DRE (along with a larger than expected PSA jump) triggered my last biopsy, which found two G9 and G10 lesions (one at, and one near, the prostate base). I mentioned...
Board: Cancer: Prostate 01-16-2020, 06:58 AM
Replies: 27
Views: 5,929
Posted By DjinTonic
Re: Starting my PCa journey

With regard to your interest in proton vs. other RT modalities:

Proton versus photon-based radiation therapy for prostate cancer: emerging evidence and considerations in the era of value-based...
Board: Cancer: Prostate 01-13-2020, 01:53 PM
Replies: 33
Views: 12,042
Posted By DjinTonic
Re: what to do now with Prostate Cancer?

If you encounter a rising PSA after a RP and go to the MSK nomogram for your statistical outcome of SRT at

https://www.mskcc.org/nomograms/prostate/salvage_radiation_therapy

you'll read:


...
Board: Cancer: Prostate 01-11-2020, 03:26 AM
Replies: 3
Views: 598
Posted By DjinTonic
Re: Whole Pelvic vs Prostate Bed RT

You can see visual comparisons of the two for SRT in these figures:
...
Board: Cancer: Prostate 01-09-2020, 06:06 PM
Replies: 21
Views: 2,879
Posted By DjinTonic
Re: 5α-Reductase Inhibitors (e.g., finasteride) and PCa risk/benefit

Jim mentioned the SpaceOar gel:

Patients considering it should be aware that there have been serious complications. I would discuss these with your doc, so you know they are aware, and they can...
Board: Cancer: Prostate 01-09-2020, 05:02 AM
Replies: 21
Views: 2,879
Posted By DjinTonic
5α-Reductase Inhibitors (e.g., finasteride) and PCa risk/benefit

This topic came up in a recent thread. Here are some recent publications I had flagged on the question of the risks/benefits of these meds for PCa, plus a couple that turned up with a very quick...
Board: Cancer: Prostate 01-07-2020, 09:04 AM
Replies: 12
Views: 1,395
Posted By DjinTonic
Re: Benign Prostate Enlargement (BPH), PSA and Prostate Cancer: When to Biopsy?

I think there is general agreement a biopsy is warranted if there are PIRADS 4 or 5 areas, regardless of other parameters. And all the studies I've come across advocate for investigating...
Board: Cancer: Prostate 01-04-2020, 05:42 AM
Replies: 11
Views: 737
Posted By DjinTonic
Long-term outcomes of active surveillance at MSK

Long-Term Outcomes of Active Surveillance for Prostate Cancer - The Memorial Sloan Kettering Cancer Center Experience [2019]

https://www.ncbi.nlm.nih.gov/pubmed/31868556



Another consoling...
Board: Cancer: Prostate 12-29-2019, 12:47 PM
Replies: 28
Views: 3,378
Posted By DjinTonic
Re: Radical Prostatectomy OR Plant Based Diet?

While RP techniques continue to have minor improvements, surgery results are more or less a fixed target and have to be compared to what are pretty much moving targets. As RT modalities change, it's...
Board: Cancer: Prostate 12-29-2019, 09:50 AM
Replies: 41
Views: 6,780
Posted By DjinTonic
Re: First post - My history and where do I go from here

Hi gp. Elevated PSA from BPH can mask a PSA contribution from PCa, which is why there was concern for me and so many (negative) biopsies. Given your family history (father) and current PSA, I...
Board: Cancer: Prostate 12-29-2019, 06:51 AM
Replies: 28
Views: 3,378
Posted By DjinTonic
Re: Radical Prostatectomy OR Plant Based Diet?

The newer the RT modality, the shorter the followup time we have to measure results. Thus RT studies for, e.g., SBRT, have necessarily used BCR rates to judge success. However, some recent studies...
Board: Cancer: Prostate 12-26-2019, 05:32 AM
Replies: 28
Views: 3,378
Posted By DjinTonic
Re: Radical Prostatectomy OR Plant Based Diet?

Thanks, Jim. Another plus about the PDQ reports is that they are updated, perhaps as often as 2 or 3 times a year. For PCa, there are also PDQ reports on

Screening:
Professional:...
Board: Cancer: Prostate 12-23-2019, 06:20 AM
Replies: 28
Views: 3,378
Posted By DjinTonic
Re: Radical Prostatectomy OR Plant Based Diet?

Hi Stephen,

For the latest in the results of serious research and professional recommendations on plant-based supplements (phytochemicals), see

Prostate Cancer, Nutrition, and Dietary...
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