It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....



High Cholesterol Message Board

  • Is it safe to take Vytorin and Niacin at the same time?

  • Post New Thread   Closed Thread
    Thread Tools Search this Thread
    Old 01-29-2005, 12:40 PM   #1
    BKSinAZ
    Newbie
    (male)
     
    BKSinAZ's Avatar
     
    Join Date: Jan 2005
    Posts: 3
    BKSinAZ HB User
    Is it safe to take Vytorin and Niacin at the same time?

    Will it have any additional cholesterol lowering benefits if I take both?
    If it is safe, what dosage of niacin per day?

     
    Sponsors Lightbulb
       
    Old 01-29-2005, 02:07 PM   #2
    Lenin
    Senior Veteran
    (male)
     
    Lenin's Avatar
     
    Join Date: Nov 2004
    Posts: 8,456
    Lenin HB UserLenin HB UserLenin HB UserLenin HB UserLenin HB UserLenin HB User
    Re: Is it safe to take Vytorin and Niacin at the same time?

    BKS,

    As a general rule, I'd say it was unsafe. You would be taking 3 cholesterol drugs all of which are capable of causing liver problems and myalgia (muscle pain.)
    Taking 3 is just ASKING for trouble.

     
    Old 01-29-2005, 02:42 PM   #3
    Ward
    Junior Member
    (female)
     
    Ward's Avatar
     
    Join Date: Jan 2005
    Posts: 27
    Ward HB User
    Re: Is it safe to take Vytorin and Niacin at the same time?

    Quote:
    Originally Posted by Lenin
    BKS, As a general rule, I'd say it was unsafe. You would be taking 3 cholesterol drugs all of which are capable of causing liver problems and myalgia (muscle pain.) Taking 3 is just ASKING for trouble.
    My understanding so far is that there are two ways of reducing cholesterol levels in the blood. One way is in the intestines by reducing the absorption of cholesterol from foods we ingest. An example of this would be soluble fiber. The other way of reducing cholesterol is lowering the amount the liver produces. An example of this would be by statins (Lipitor etc.) I am curious about the method of reduction for many remedies suggested. For example does niacin work in the intestines or the liver? Where do omega-3 fatty acids work?

    My high cholesterol is probably caused by over-manufacture in the liver. So is soluble fiber not particularly beneficial to me?

    Many thanks.

     
    Old 01-29-2005, 04:08 PM   #4
    Lenin
    Senior Veteran
    (male)
     
    Lenin's Avatar
     
    Join Date: Nov 2004
    Posts: 8,456
    Lenin HB UserLenin HB UserLenin HB UserLenin HB UserLenin HB UserLenin HB User
    Re: Is it safe to take Vytorin and Niacin at the same time?

    Atually WARD there are several ways of reducing cholesterol in the blood.

    Among them is eating less saturated and trans fats (dietary methods), by blocking the action of HmgCoA reductase in the liver (how statins work), attaching to cholesterol rich bile in the intestines thus preventing it's recycling (bile sequesterants and probably the effect of a high soluble fiber diet), and using fibrates like gemfibrozil that work in the liver also by causing less fat to be produced overall.
    Niacin methhodology is not too well defined but certainly involves the liver in a couple of ways as well:
    Quote:
    It may
    involve several actions including partial inhibition of release of free fatty acids from adipose
    tissue, and increased lipoprotein lipase activity, which may increase the rate of chylomicron
    triglyceride removal from plasma. Niacin decreases the rate of hepatic synthesis of VLDL
    and LDL, and does not appear to affect fecal excretion of fats, sterols, or bile acids.
    So you can see that almost EVERY method involves intervention at the liver with the least liver dependent being the bile sequesterants which aren't very popular these days...hard on digestion.

    I guess the root word "LIVE" was well applied to the LIVER.

    Last edited by Lenin; 01-29-2005 at 04:14 PM.

     
    Old 01-29-2005, 04:14 PM   #5
    ARIZONA73
    Senior Veteran
    (male)
     
    ARIZONA73's Avatar
     
    Join Date: Aug 2002
    Location: Fords, N.J. USA
    Posts: 2,263
    ARIZONA73 HB UserARIZONA73 HB UserARIZONA73 HB UserARIZONA73 HB User
    Re: Is it safe to take Vytorin and Niacin at the same time?

    I would say niacin works in the liver. But, as Lenin said, it probably isn't a good idea to start taking niacin on top of a statin without consulting with your doctor first. Although statins excel at lowering TC and LDL, niacin possessus other advantages. It's ability to increase HDL is unsurpassed. It can potentially lower lipoprotein(a), another dangerous risk factor, and it is capable of promoting a favorable shift towards increased LDL particle size, or Pattern A LDL, the more benign form of LDL. In addition, it is a great circulatory agent.

    If you are currently taking a statin such as Lipitor or Zocor, and wish to include the benefits of niacin, why not ask your doctor about switching to Advicor. Advicor is a statin and niacin (Niaspan) all in one pill. In fact, I'm puzzled that it is seldom mentioned on these boards. We hear so much about Lipitor, Zocor, and Crestor. But that's about it. Overall, I tend to believe that Advicor would be more advantageous if you must choose between statins. Otherwise, my preference would naturally be plain, simple niacin.
    __________________
    "Men and nations will act rationally when all other possibilities have been exhausted."

     
    Old 02-04-2005, 05:48 PM   #6
    Sispresso
    Newbie
    (female)
     
    Sispresso's Avatar
     
    Join Date: Jan 2005
    Posts: 4
    Sispresso HB User
    Re: Is it safe to take Vytorin and Niacin at the same time?

    Health Canada, the Canadian equivalent to the FDA today put out a warning on EZTIMIBE which is one of the drugs in VYTORIN. As well as the following adverse effects, EZETIMIBE ( or Zetia ) may negatively interact with warfarin:

    ~~~~~~~~~~~~

    Subject: Association of Ezetrol® (ezetimibe) with myalgia, rhabdomyolysis, hepatitis, pancreatitis, and thrombocytopenia

    The Product Monograph for Ezetrol® (ezetimibe) has been updated to include information from international post-marketing reports of rare, and in some cases serious, adverse events. The Patient Information section is being updated to inform patients of the signs and symptoms of hepatic, muscle, and pancreatic adverse events, for which early consultation with a physician is recommended.

    Additional reports of myalgia, many accompanied by elevated creatine phosphokinase (CK) values, have been reviewed by Health Canada.

    The Warnings, Precautions, and Adverse Events sections are being updated to reflect the occurrence of the following adverse events in patients taking Ezetrol® (ezetimibe) alone or in combination with a statin:

    * myalgia;
    * rhabdomyolysis;
    * hepatitis;
    * acute pancreatitis;
    * thrombocytopenia; and
    * suspected interaction between Ezetrol® (ezetimibe) and warfarin

    While it is not possible to definitively establish a causal relationship between these adverse events and the use of Ezetrol® (ezetimibe), the Product Monograph changes and the following recommendations are based on the potentially serious nature of these events.

    Adverse muscle events:

    Myalgia

    Myalgia has been reported in patients treated with Ezetrol® (ezetimibe).

    Importantly, a number of patients treated with Ezetrol® (ezetimibe) in whom myalgia occurred, had previously experienced myalgia (with or without elevated CK levels) with statin therapy. Patients with a history of statin intolerance (myalgia with or without elevated CK levels) should be closely monitored for adverse muscle events during treatment with Ezetrol® (ezetimibe).

    Rhabdomyolysis

    Patients treated with Ezetrol® (ezetimibe), who experience persistent muscle pain, should be instructed to contact their physicians for evaluation of the possibility of rhabdomyolysis. In most reported cases, rhabdomyolysis resolved when the drugs were discontinued.

    Adverse hepatic events:

    Elevations of liver transaminases and cases of hepatitis have been reported in patients treated with Ezetrol® (ezetimibe). Liver function monitoring is recommended when therapy with Ezetrol® (ezetimibe) is initiated in patients treated or about to begin treatment with a statin.

    Health care professionals should be aware that the use of Ezetrol® (ezetimibe) in combination with a statin is contraindicated in patients with active liver disease or unexplained persistent elevations of liver transaminases.

    Care should be exercised in the use of Ezetrol® (ezetimibe) in patients with active liver disease or unexplained persistent elevations of liver transaminases.

    Adverse pancreatic events:

    Physicians should consider the diagnosis of pancreatitis in patients who develop sudden acute abdominal pain during therapy with Ezetrol® (ezetimibe).

    Suspected interaction between Ezetrol® (ezetimibe) and warfarin:

    Additional International Normalized Ratio (INR) measurements are recommended in patients treated with warfarin, and in whom Ezetrol® (ezetimibe) is initiated.

    The identification, characterization, and management of marketed health product-related adverse reactions are dependent on the active participation of health care professionals in adverse reaction reporting programmes. Any occurrences of muscle, hepatic, pancreatic, hematologic, suspected interaction with warfarin or other serious and/or unexpected adverse reactions in patients receiving Ezetrol® (ezetimibe) should be reported to Merck Frosst/Schering Pharmaceuticals or Health Canada at the following addresses:

     
    Old 02-04-2005, 07:50 PM   #7
    ARIZONA73
    Senior Veteran
    (male)
     
    ARIZONA73's Avatar
     
    Join Date: Aug 2002
    Location: Fords, N.J. USA
    Posts: 2,263
    ARIZONA73 HB UserARIZONA73 HB UserARIZONA73 HB UserARIZONA73 HB User
    Re: Is it safe to take Vytorin and Niacin at the same time?

    Well, I'm certainly glad that my father refused to open up those samples of Zetia that the doctor gave to him, although I thought that it would be completely harmless if he decided otherwise. Thanks for that information! Apparently Canada is far more truthful and honest regarding prescription drug dangers than the U.S.
    __________________
    "Men and nations will act rationally when all other possibilities have been exhausted."

    Last edited by ARIZONA73; 02-04-2005 at 07:58 PM.

     
    Old 02-05-2005, 07:43 AM   #8
    jtu91952
    Inactive
     
    Join Date: Jan 2004
    Location: western ny
    Posts: 942
    jtu91952 HB User
    Re: Is it safe to take Vytorin and Niacin at the same time?

    I so agree. I knew zetia was bad for me. I tried to take it twice for a month and i started having problem in my stomach (under the rib cage) and in my back where the liver is located. My dr brushed it off as nothing and wanted me to continue taking it. I refused.

    Thanks for the info.

     
    Closed Thread

    Related Topics
    Thread Thread Starter Board Replies Last Post
    Is it safe? 2 light beers with Niacin and RYR. pohaku High Cholesterol 11 09-15-2007 11:05 AM
    Husband cut Vytorin pills in half...surprisingly GREAT results.... Tenacious High Cholesterol 26 02-05-2007 04:06 PM
    Should I take cholesterol medicine? rapiniluvr High Cholesterol 22 01-12-2007 07:47 AM
    Vytorin side effects? Cher2005 High Cholesterol 11 09-25-2006 05:19 AM
    Vytorin 10/20 - 27yr old male. derrick_cr_tn High Cholesterol 10 07-11-2006 08:41 PM
    2 months after Vytorin 10/40, unbelievable results linda115 High Cholesterol 18 08-08-2005 07:12 AM




    Thread Tools Search this Thread
    Search this Thread:

    Advanced Search

    Posting Rules
    You may not post new threads
    You may not post replies
    You may not post attachments
    You may not edit your posts

    BB code is On
    Smilies are On
    [IMG] code is Off
    HTML code is Off
    Trackbacks are Off
    Pingbacks are Off
    Refbacks are Off




    Sign Up Today!

    Ask our community of thousands of members your health questions, and learn from others experiences. Join the conversation!

    I want my free account

    All times are GMT -7. The time now is 03:01 PM.





    © 2021 MH Sub I, LLC dba Internet Brands. All rights reserved.
    Do not copy or redistribute in any form!