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    Old 01-22-2007, 09:03 AM   #16
    Lenin
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    Re: Niacin Studies

    I am very happy with time-release formulations at 500 mg. I have TRIED several times to take the No-Flush at a dosage of 1000 mg. and find the flush to be too much to bear on a daily basis.

    So although, claims can probaly be honestly made that "most people can take 2,000 mg. Slo-Niacin (in whatever form) without discomfort", those "most people" don't include me.

    So, I am/must be content with tolerable HDL upping of niacin that I get with 500 mg....somewhere between +5 and +8 mg./dL. After all 40 is a lot better than 35...or the miserable 28 before the Lipitor.

    Last edited by Lenin; 01-22-2007 at 09:05 AM.

     
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    Old 01-22-2007, 04:33 PM   #17
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    Re: Niacin Studies

    Lenin (and anyone else),

    I'm considering trying a bottle of the 750 mg Slo-Niacin for 60 days. Do you think it's too much (coupled with the Vytorin 10/20)? The literature seems to indicate that one shouldn't take > 1 gram with statin. I was thrilled when my HDL hit 42 with the Vytorin 10/20 and 500 mg Slo-Niacin . I visited my retina specialist this past friday for my 6 month check-up (detached retina with sclaria buckle repair in 1997 ). Anyway, he was a family physician b4 specializing in retina diseases. We were discussing cholesterol drugs (I have started the vytorin since my last visit with him) and he point blank said that his biggest concern was the pharmacy companies will to make profits, at any cost. It was refreshing to hear a doctor with concern with statins (he had a bad experience himself while on Zocor) and I guess that's why we're on here trying to look out for one another . If anything, this board causes me to proceed rather cautiously .

    I'm glad you dug this thread out of the vault. It is motivating to try and increase my HDL even further before my next labs in April.

     
    Old 01-22-2007, 06:02 PM   #18
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    Re: Niacin Studies

    Lenin,

    Did you up your dose of slo-niacin to 750 mg? I've read on the bottle that the 500 mg can be split at the score line so no need to buy the 750 if I decide to up my dose. One concern that you've expressed before is a tripled approach (Zocor + Zetia + Niacin). I need to do some research on that one before deciding. One of the Slo-Niacin studies was a triple (niacin lovastatin and colestipol). Target LDL of <100 was reached by 8 months by 83% of the study group. These folks were getting 500 mg of Niacin or Slo-Niacin x 4/day, 20 mg lovastatin x 2/day and 10 g colestipol x 2/day. What is colestipol??? Anyway, it looks like I'm doing as well or better with Vytorin 10/20 and the 500 mg slo-niacin .

     
    Old 01-23-2007, 04:54 AM   #19
    Lenin
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    Re: Niacin Studies

    Judge,

    Actually I DIDN'T dig up this old thread, JohhnyO did.

    I tried the 750 mg. for a couple days and noticed that I was flushing if I didn't go to sleep immediately after taking it. Flushing frightens me since it seems to oftentrigger bouts of seborrheic dermatitis that persists for several days...which I HATE! So I went back to 500 mg. (currently Dixon's TIME RELEASED NIACIN that I found a dozen bottles of in a bargain bin.)

    Cholestipol is a resin that acts as a bile acid sequestrant...it attaches to the cholesterol in bile and prevents it's resorption so you excrete it. Your liver searches for more cholesterol to make more bile and pulls it out of the blood, thus lowering it. It's more innocuous than the ezetimibe in the Vytorin.

    Try the 750 or 1000 mg. SLO-NIACIN and after a month or two see how your liver enzymes (and HDL) look.

    Last edited by Lenin; 01-23-2007 at 04:57 AM.

     
    Old 01-23-2007, 11:38 AM   #20
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    Re: Niacin Studies

    There's a nice little article in today's NYT about niacin.

     
    Old 01-23-2007, 05:06 PM   #21
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    Re: Niacin Studies

    Thanks Connie. It was a great article about the ability of Niacin to boost HDL and showed some of the ongoing work with Niacin, including Merck's development, which I had read a bit about a while back. To me, it helps me know that Slo-Niacin is right for me because the Dr. Brown that the article refers to has done studies with Slo-Niacin in combination with Statins, by itself, etc. in the past. If anyone is interested, the manufacturer of Slo-Niacin has a monograph with various studies using Niacin (and Slo-Niacin). If interested, just check one of my earlier posts in this thread.

     
    Old 01-24-2007, 06:56 AM   #22
    Lenin
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    Re: Niacin Studies

    Connie,

    Quote:
    Until then, consider this: If it means preventing a heart attack, maybe it is better to put up with flushing than to wait for the next blockbuster.
    Obviously the author, Michael Mason, never had a niacin flush. ...that flushy-face color is just about right...maybe a LITTLE more PURPLE!

    Last edited by Lenin; 01-24-2007 at 06:56 AM.

     
    Old 01-24-2007, 07:47 AM   #23
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    Re: Niacin Studies

    I take 200mg 4x a day of plain old Kroger brand niacin together with Lipitor 20mg.

    When I first started taking niacin I seem to remember reading that the plain was much more effective.

    Would some one please explain the differences between plain niacin, flush free niacin and extended or time release niacin? What is Slo-niacin?

    Many thanks,
    Tina

     
    Old 01-24-2007, 05:11 PM   #24
    Connie122516
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    Re: Niacin Studies

    Quote:
    Originally Posted by Lenin View Post
    Obviously the author, Michael Mason, never had a niacin flush. ...that flushy-face color is just about right...maybe a LITTLE more PURPLE!
    Amen!!! I first SAW a niacin flush about 48 hours after my stent was put in, and I was recuperating at my sister's house. (I live more than 2 hours from the hospital, and they wouldn't let me drive home by myself for a few days). She neglected to tell me she had just started a large dose of niacin, and woke me up in the middle of the night freaking out. She was supposed to be taking care of me, and it was the other way around!

    Several months later, after my doctors finally put me on the stuff, I learned first hand. Luckily, it doesn't happen much anymore but it's something I can sure do without!!!

     
    Old 01-24-2007, 05:27 PM   #25
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    Re: Niacin Studies



    That's about as close as I can come to explaining how it felt when I worked my way from 500 mg to 1000 mg of Niaspan!

    In all seriousness, I am very thankful to Lenin, the former spokesperson for Slo Niacin, for introducing me to a much more tolerable form of Niacin. It (500 mg) is much less harsh in terms of the flushing and the impact on my hdl (coupled with the vytorin 10/20) has been fantastic.

     
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