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    Old 10-21-2007, 06:29 PM   #1
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    what if igm p23 is present?

    what if igm p23 is present?

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    Old 10-22-2007, 05:01 AM   #2
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    Re: what if igm p23 is present?

    Hi a95tanu, welcome to the board!

    Below is the breakdown of the Western Blot bands:

    9 cross-reactive for Borrellia
    12 specific for Bb
    18 unknown
    20 cross-reactive for Borrellia
    21 unknown
    22 specific for Bb, probably really the 23/25 band
    23-25 outer surface protein C (OspC), specific for Bb
    28 unknown
    30 unknown; probably an outer surface protein; common in European and
    one California strain
    31 outer surface protein A (OspA), specific for Bb
    34 outer surface protein B (OspB); specific for Bb
    35 specific for Bb
    37 specific for Bb
    38 cross-reactive for Bb
    39 is a major protein of Bb flagellin; specific for Bb
    41 flagellin protein of all spirochetes; this is usually the first to appear after a Bb infection and is specific for all Borrellia
    45 cross-reactive for all Borellia (sometimes people with Lyme who have
    this band positive also have the co-infection Ehrlichiosis)
    50 cross-reactive for all Borrellia
    55 cross-reactive for all Borrellia
    57 cross-reactive for all Borrellia
    58 unknown but may be a heat-shock Bb protein
    60 cross reactive for all Borrellia
    66 cross-reactive for all Borrelia, common in all bacteria
    83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane
    93 unknown, probably the same protein in band 83, just migrates differently in some patients

    The IgM tests for a more recent infection, the IgG a longer standing one.

    No test for Lyme disease is completely reliable, and results can vary by lab. The CDC requires several Lyme-specific bands to be present for the test to be considered positive; however, many people who have Lyme do not have this many bands. Band 23-25 is a Lyme specific band. It is significant if it is positive.

    Which lab did the test? It is important to be tested by a Lyme lab such as IgeneX in Palo Alto, CA. They use more sensitive testing and list more bands on the Western Blot.

    Do you have symptoms? How long have you had them? Below is a Lyme symptom list. You can have any combination of symptoms.

    Unexplained fevers, sweats, chills, or flushing
    Unexplained weight change--loss or gain
    Fatigue, tiredness, poor stamina
    Unexplained hair loss
    Swollen glands
    Sore throat
    Testicular pain/pelvic pain
    Unexplained menstrual irregularity
    Unexplained milk production: breast pain
    Irritable bladder or bladder dysfunction
    Sexual dysfunction or loss of libido
    Upset stomach
    Change in bowel function-constipation, diarrhea
    Chest pain or rib soreness
    Shortness of breath, cough
    Heart palpitations, pulse skips, heart block
    Any history of a heart murmur or valve prolapse?
    Joint pain or swelling
    Stiffness of the joints, neck, or back
    Muscle pain or cramps
    Twitching of the face or other muscles
    Neck creeks and cracks, neck stiffness, neck pain
    Tingling, numbness, burning or stabbing sensations, shooting pains
    Facial paralysis (Bell's Palsy)
    Eyes/Vision: double, blurry, increased floaters, light sensitivity
    Ears/Hearing: buzzing, ringing, ear pain, sound sensitivity
    lncreased motion sickness, vertigo, poor balance
    Lightheadedness, wooziness
    Confusion, difficulty in thinking
    Difficulty with concentration, reading
    Forgetfulness, poor short term memory
    Disorientation: getting lost, going to wrong places
    Difficulty with speech or writing
    Mood swings, irritability, depression
    Disturbed sleep-too much, too little, early awakening
    Exaggerated symptoms or worse hangover from alcohol

    It is very important to see a kowledgeable doctor. Many doctors do not understand Lyme and treat with outdated protocols.

    Besides Lyme, ticks can also transmit several co-infections including Babesiosis, two types of Ehrlichiosis (HME & HGE), Bartonella, and Mycoplasma. Many people who have Lyme are co-infected. It may affect treatment choice and progress. It is important to be tested for these by a Lyme reputable lab such as IgeneX in Palo Alto, CA.

    If you need a doctor recommendation, let us know. There are some excellent ones in NY.

    It is also important to learn as much as possible. I recommend reading Dr. Joseph Burrascano's 2005 Diagnostic Hints and Treatment Guidelines For Lyme and Other Tick Borne Illnesses (on-line). He is one of the top Lyme doctors in the country, and many Lyme doctors follow his protocols. I also recommend the book "Everything You Need To Know about Lyme Disease
    (2nd edition)" by Karen Vanderhoof-Forschner.

    Old 11-08-2007, 01:21 PM   #3
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    Cool Re: what if igm p23 is present?

    Hello Ticker........if you are out there. And anyone else who might like to help me solve a puzzle! I would really appreciate any help I can get understanding this. I have a similar situation to A95tanu. I'm trying to figure out when I most likely contracted this disease. My MD tested me on July 8 because I was having a lot of unexplained symptoms: fatigue, HA's, nausea, sleeping problems, mood problems, night sweats, hair loss. She then told me the test was negative. I went on for the next few months with worsening symptoms and new ones: heart palpitations, heavy breathing, extreme anxiety, almost like panic attacks, terrible insomnia, unable to concentrate or keep track of my thoughts, and sometimes when I talk the words come out backwords and it's like my response time is abnormally delayed.

    Anyway, I got a bit side-tracked, but with the worsening symptoms, we retested again on November 1 and she called and told me I was Positive for Lyme and that I must have got it sometime between the two tests. I'm now on Doxy 100mg for 4 weeks........which is good. I went to the MD's office and requested both Lyme tests and as I am researching, and after reading your post, I think the first test can be interpreted as Positive, meaning I would have had the lyme probably at least a month before that. Here's my reasoning, and I hope you can help me assess.

    JULY 8'th TEST results showed
    IgG of 41 reactive (all others not reactive)
    IgM of 23 reactive (all others including 41 nonreactive)
    *Thus only one band reactive, so the test was interpreted as NEGATIVE

    IgG of 41 reactive (all others not reactive)
    IgM of 23 and 41 active
    *Thus two bands reactive, so the test was interpreted as POSITIVE

    My theory is that I was actually positive on July 8'th because 23 is specific for Lyme, and there is no other reason it would be reactive. As I understand it, the 41 is questionable because it's not specific for Lyme, but being that 23was reactive on IgM on both tests, I'm thinking that pretty much means I must have had it at the time of the first test. Any help understanding this would be greatly appreciated.


    Old 11-22-2007, 01:18 AM   #4
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    Re: what if igm p23 is present?

    hi gypsygirl
    Did I understand that they put you on only 100 mg doxy It sounds way too loo a dose I belive ehrn I was on the doxcy I took 100mg 3x's a day
    Ticker s so good about responding to everyonr She is resource to information
    Good luck with everything Keep in mind youa nd only you sre yoir front line advocate
    good luck with your treatment I haven been on IV rocephin for 11 months Doxcu before that

    Old 11-22-2007, 09:44 AM   #5
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    Re: what if igm p23 is present?

    I had my IGM 23 band show up positive. The kicker is that I had the tick bite about 13 yrs ago. I have recently been showing symptoms the last 3 yrs and my llmd is positive that it is lyme. He says its odd that the IGM band would be positive with a chronic illness. What gives??

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