It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....



Smoking Cessation Message Board

  • Stopping smoking with St.John Wort and Selegiline

  • Post New Thread   Closed Thread
    Thread Tools Search this Thread
    Old 05-12-2004, 01:53 PM   #1
    bradcured
    Junior Member
     
    bradcured's Avatar
     
    Join Date: Dec 2003
    Location: Detroit
    Posts: 23
    bradcured HB User
    Stopping smoking with St.John Wort and Selegiline

    I've been off cigarettes 12 days, with absolutely no nicotine cravings. I'm supplementing myself with 900 mg of St John Wort extract (3x/daily) and 5mg of Selegiline (Deprenyl). Both substances seem to have an effect on my nicotine addiction. Here are the studies which show its effects:

    ST JOHN'S WORT
    ----------------
    http://biopsychiatry.com/hypericumsmok.htm

    Hypericum perforatum attenuates nicotine withdrawal signs in mice
    by

    Catania MA, Firenzuoli F, Crupi A, Mannucci C, Caputi AP, Calapai G.
    Department of Clinical and Experimental Medicine and Pharmacology,
    Section of Pharmacology, School of Medicine, University of Messina,
    Via Consolare Valeria,
    Policlinico Universitario Torre Biologica 5 degrees piano,
    98125, Messina, Italy.
    Psychopharmacology (Berl) 2003 Apr 29

    ABSTRACT
    RATIONALE. Hypericum perforatum is used as a natural antidepressant, and other antidepressants have been marketed to aid in smoking cessation. OBJECTIVE. We investigated the effects of an extract of Hypericum perforatum (Ph-50) on withdrawal signs produced by nicotine abstinence in mice. METHODS. Nicotine (2 mg/kg, four injections daily) was administered for 14 days to mice. Different doses of Ph-50 (125-500 mg/kg) were administered orally immediately after the last nicotine injection. In another experiment, Ph-50 (500 mg/kg) was orally administered in combination with nicotine, i) starting from day 8 until the end of the nicotine treatment period, or ii) during nicotine treatment and after nicotine withdrawal, or iii) immediately after the last nicotine injection. On withdrawal from nicotine, all animals were evaluated for locomotor activity and abstinence signs. RESULTS. The locomotor activity reduction induced by nicotine withdrawal was abolished by Ph-50, which also significantly and dose-dependently reduced the total nicotine abstinence score when injected after nicotine withdrawal. CONCLUSIONS. These data show that treatment with Hypericum perforatum attenuates nicotine withdrawal signs in mice. Further studies are necessary to test the possibility that it may be used for smoking cessation treatment in humans.

    SELEGILINE (DEPRENYL)
    -----------------------
    http://www.deprenyl.info/deprenyl-58.htm

    Effects of selegiline (l-deprenyl) during smoking and short-term abstinence.

    Houtsmuller EJ, Thornton JA, Stitzer ML.

    Behavioral Pharmacology Research Unit
    Johns Hopkins University School of Medicine
    Bayview Medical Center
    5510 Nathan Shock Drive,
    Baltimore, MD 21224-6823, USA [email protected]***
    Psychopharmacology (Berl) 2002 Sep;163(2):213-20

    Abstract

    RATIONALE. Changes in dopamine level are thought to play an important role in both smoking reward and withdrawal symptoms during abstinence. Medications that modulate dopamine levels may have beneficial effects on both withdrawal symptom levels and on response to smoking lapses during abstinence.

    OBJECTIVES. To examine the effects of the selective MAO-B inhibitor selegiline on withdrawal symptoms, smoking behavior and smoking satisfaction ratings.

    METHODS. Fifteen smokers received selegiline (10 mg/day) and placebo (in counterbalanced order) on Monday through Thursday of 2 study weeks, separated by a 2-week washout. During each study week, ad lib smoking sessions were scheduled to assess smoking behavior both before and after a brief period of abstinence. Subjective withdrawal symptoms and mood were measured daily, and a modified Stroop test sensitive to withdrawal was scheduled during the period of abstinence.

    RESULTS. Selegiline decreased craving, especially during abstinence, and impaired performance on the modified Stroop test during subjects' attempts to abstain. Medication also reduced number of cigarettes smoked and smoking satisfaction ratings during the smoking sessions both before and after the brief abstinence attempt.

    CONCLUSION. These results are consistent with an important role of dopamine in smoking behavior and abstinence. They suggest that pharmacological reduction of MAO-B levels during the early part of a quit attempt may aid in smoking cessation.

     
    Sponsors Lightbulb
       
    Old 05-12-2004, 11:03 PM   #2
    Deda
    Senior Veteran
    (female)
     
    Join Date: Jul 2003
    Location: Northern C
    Posts: 2,327
    Deda HB User
    Re: Stopping smoking with St.John Wort and Selegiline

    bradcured--

    Wow, that's really great that this worked for you, and you were able to quit, (thus far) without any cravings. Is the Deprenyl a prescription med? Was this recommended to you by a Dr., or did you just read about it and decide to try it? Anyway, whatever the case, CONGRATULATIONS to you!!!
    DEDA

     
    Old 05-18-2004, 09:56 PM   #3
    bradcured
    Junior Member
     
    bradcured's Avatar
     
    Join Date: Dec 2003
    Location: Detroit
    Posts: 23
    bradcured HB User
    Re: Stopping smoking with St.John Wort and Selegiline

    Yes, Deprenyl can be found at online smart drugs web sites. Its an anti-oxidant, neuro-protectant, anti-depressant, anti-aging med - more info check out www.deprenyl.info.

    I found the study which I posted in my earlier msg - about deprenyl and smoking and figured out that i should give it a try. At the same time Ive found SJW study and also tossed that into the anti-smoking mix. And it works great. 19 days and still going strong!

     
    Old 05-19-2004, 06:37 AM   #4
    retiree
    Junior Member
     
    retiree's Avatar
     
    Join Date: May 2004
    Location: Ohio
    Posts: 18
    retiree HB User
    Re: Stopping smoking with St.John Wort and Selegiline

    Hey Bradcured, Great job, keep us updated on your progress. How long did it take for the St John Wort to get into your system and begin taking effect? How long did you take it before you quit? I am also trying it. Thanks in advance.

     
    Old 05-25-2004, 06:17 AM   #5
    bradcured
    Junior Member
     
    bradcured's Avatar
     
    Join Date: Dec 2003
    Location: Detroit
    Posts: 23
    bradcured HB User
    Re: Stopping smoking with St.John Wort and Selegiline

    It took 7 days to actually feel no-need to smoke cigs (I have NO CRAVINGS, first time since 4 yrs of my smoking)

     
    Closed Thread

    Related Topics
    Thread Thread Starter Board Replies Last Post
    Chantix (Reducing/Stopping) paulagizmo Smoking Cessation 37 03-19-2007 06:44 AM
    Can St John's Wort decrease opiate effectiveness Blasterboy Pain Management 6 01-21-2006 09:28 PM
    ST JOHN'S WORT for Depression Instead Sustasha Depression 7 10-20-2004 10:53 AM
    Birth Control and St.John's Wort WhiskersOnKittens Birth Control 2 06-25-2004 05:13 PM
    Selegiline/Deprenyl/Jumex - for smoking stoping? bradcured Smoking Cessation 0 04-07-2004 10:13 PM
    Weight Gain Issues related to stopping smoking Invincible Smoking Cessation 55 12-31-2003 09:58 PM
    St. John's Wort? kurt25 Obsessive Compulsive Disorder (OCD) 2 09-02-2003 03:31 PM
    A word about St. John's Wort & the pill mhjada Depression 4 03-30-2003 09:06 PM
    St. John's Wort... Interactions ? Just-A-Boy Alternative Medicine 1 10-20-2002 11:15 AM




    Thread Tools Search this Thread
    Search this Thread:

    Advanced Search

    Posting Rules
    You may not post new threads
    You may not post replies
    You may not post attachments
    You may not edit your posts

    BB code is On
    Smilies are On
    [IMG] code is Off
    HTML code is Off
    Trackbacks are Off
    Pingbacks are Off
    Refbacks are Off




    Sign Up Today!

    Ask our community of thousands of members your health questions, and learn from others experiences. Join the conversation!

    I want my free account

    All times are GMT -7. The time now is 11:56 PM.





    © 2021 MH Sub I, LLC dba Internet Brands. All rights reserved.
    Do not copy or redistribute in any form!