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Negative Effects On Body from High TSH

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Old 01-12-2007, 12:01 PM   #1
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Join Date: Dec 2006
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Zilct HB User
Question Negative Effects On Body from High TSH

Hello everyone,

I am desperatly searching for information from anyone, or ideas about where to search. I need information regarding any negative effects on the body from constant high TSH exposure.

My TSH runs very high. I get hypo symptoms when we get to 60-90 TSH levels. I get hyper syptoms when I get within 5-10 TSH. Right now I am at greater than 75 (lab is kind of screwy) on 75mcg of Thyroxine and feeling mild symptoms of hypo (none bad enough to keep me from daily life).

My new endo thinks PRTH. She says I may always run high TSH, and have little to know symptoms in a certain range. Well that scares me only because I am young, and I am worried about continuous high TSH and my body. I want another child within the next three years. This is also a worry with high TSH.

Any thoughts and ideas are greatly appreciated.(sorry for any misspellings)


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Old 01-12-2007, 03:36 PM   #2
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Join Date: Oct 2006
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accessn12 HB Useraccessn12 HB Useraccessn12 HB User
Re: Negative Effects On Body from High TSH

Howdy Liz,

You may not believe this but high TSH in and of itself has no adverse affect on the body whatsoever. It is the thyroid hormones themselves (T4 and T3) that have an affect on the body. The high TSH seen in PRTH is a compensatory mechanism. People with RTH always have higher than normal TSH than you would see in a normal person. Most people with PRTH are euthyroid and are never aware of the fact that they have high TSH and thyroid hormones because the body is properly compensating for the need for more thyroid hormone. If they are predominately hyper it's called PRTH and if they are predominately hypo they call it GRTH. To complicate it even further it can swing from one to the other over a persons lifetime. In other words, it can cycle with a person sometimes feeling hypo, sometimes feeling hyper and sometimes feeling perfectly normal.

It is a very complex mechanism involving thyroid hormone receptors and a mutation in one of the thyroid hormone receptor genes. It's something that varies a great deal from person to person with PRTH.

Basically PRTH refers to a defect where a patient is hypothyroid at the level of the pituitary. The pituitary needs more feedback from the circulating thyroid hormones before it finally stops putting out TSH. Then it gets complicated from there. Depending on what other organs in the body are affected by that particular gene mutation, they will appear either hypo, hyper or euthyroid and things can change over time.

PRTH has an excellent prognosis. It is considered a much more benign condition than the autoimmune thyroid diseases. It's biggest problem has been that very few doctors recognize it and patients are usually treated with anti-thyroid meds, RAI or surgery and then a mess is created.

The treatment of choice for PRTH is the beta blocker Atenolol if tachycardia is a problem and if necessary, the use of thyroid hormone analogs (DT4 or TRIAC which is not easy to get in the US) or high doses of T3 on an every other day basis. Sometimes no treatment at all is needed. Treatment is very successful and a person with PRTH can lead a very normal life, have kids and live a long happy, healthy life.

Congratulations. If I have any luck with the endo, I'll probably be joining you with this diagnosis in March. I have not doubt that that is going to be my diagnosis too.


Old 01-13-2007, 01:50 PM   #3
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Join Date: Dec 2005
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Archie343 HB User
Re: Negative Effects On Body from High TSH

I'm glad Helen got here first. I was going to say you don't need to worry about high TSH hurting you but I couldn't possibly have backed up that gut-feeling with hard data the way Helen has.

Good luck.

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