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TG vs. TG AB?

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Old 04-16-2008, 11:22 AM   #1
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TG vs. TG AB?

I am waiting for a call back from my dr. but I'm having some trouble getting this clarified with her. She initially told me that I have elevated antibody levels, but when I got copies of my lab work, it clearly states that both TPO and TG antibodies are in the normal range. It is thyroglobulin (TG) that is elevated. I spoke with the nurse and she was trying to tell me that it's essentially the same thing. My understanding is that it's not. The dr. left a message for me yesterday saying that "only 10% of people with hypothyroid have this AB elevated, as opposed to TPO AB." But I *don't* have elevated AB levels.

I'm a little confused and would like to understand what is really going on before I talk to her tomorrow. For one thing I'd like to have a sense of if she actually knows what she's talking about. I'm not trying to challenge her knowledge, but it seems obvious to me that there's a difference between TG and TG-AB. And that the presence of each would imply a different underlying cause and possibly a different treatment. But I'm not an expert either.

For the record, my TSH is borderline high (it's been between 2.7 and 4.1). FT4 is in the normal range, but low. FT3 is also normal and low, but lower than T4, %-wise.

Thanks for any insight into this.


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Old 04-17-2008, 05:16 AM   #2
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Re: TG vs. TG AB?



Old 04-17-2008, 06:33 AM   #3
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Re: TG vs. TG AB?

Elevated TG is used in measuring and following malignant thyroid cancer patients. I am not saying you have thyroid cancer by any means. It goes back to the what is normal for you arguement. We are all individuals and thus subject to variations.

TGAb are antibodies that attack the enzymes that produce TG. TPOAb are the antibodies that attack TPO enzymes needed to stimulate the thyroid and make more thyroxine (T4). So if your antibodies were normal and you have a nodule/nodules with raised TG.. I would think biopsies of all nodules would be a must.

If we learn by our mistakes, I am working on one hell of an education.

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