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Can Melatonin and Vitamin B-6 cause nerve problems?

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Old 04-23-2004, 03:13 PM   #1
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Can Melatonin and Vitamin B-6 cause nerve problems?


I am currently taking one tablet of Melatonin before sleeptime at night. I am doing it because I have sleep problems lately due to nerve pains and stress/anxiety. I know that Melatonin is made up of Vitamin B-6. Vitamin B-6 is said to both good or bad for your nerves depending on how much we intake. So, is Melatonin not an advantage in my case? Thanks.

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Old 04-23-2004, 05:17 PM   #2
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Re: Can Melatonin and Vitamin B-6 cause nerve problems?

Melatonin isn't exactly made up of vitamin B-6. Melatonin is a hormone, and vitamin B-6 will help support your body's natural production of this hormone. Vitamin B-6 is generally safe in doses up to 500mg. With doses higher than 500mg, you run the risk of developing sensory neuropathy, a numbness or tingling in the arms or legs, which is reversible once the dosage is cut back.

Old 04-24-2004, 07:55 AM   #3
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Re: Can Melatonin and Vitamin B-6 cause nerve problems?

For vitamin B6 (pyridoxine) supplements, 500 mg/d has been identified to be the lowest dosage associated with observable side effects (sensory neuropathy, though reversible), while 200 mg/d is the dosage level with no observable adverse effects. Some studies have reported sensory neuropathy between 200 mg/d and 500 mg/d... Other conflicting studies exist. The time it took for adverse effects to surface varied, but duration of supplement usage ranged from a few months to a few years.

With 200 mg/d as the agreed upon dosage level that carries no observable adverse effects and taking into account an uncertainty factor, the tolerable upper limit for vitamin B6 in adults (aged 18-50) has been set to 100 mg/d.

Therefore, dosages of vitamin B6 higher than the upper limit can increase the possibility for sensory neuropathy.

Last edited by scribbles; 04-24-2004 at 08:01 AM.

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