After 3 courses of accutane, tetracyclin, monocyclin, benzaclin, murad, proactive, retin a, retin micro, tazorac, and everything over the counter - nothing worked. After two months of Skintactix I am 100% clear. I have had consistant acne/problem skin for 10 years and have had every emotional stress that goes along with it. I am one of the people who thought I would never have clear skin. This stuff worked.