I've been where you ladies are at. Tried everything from accutane to yasmin (which works by the way I just started losing my hair from the shift in hormones), antibiotics, diet ( reducing refined sugars and trigger foods will help control cystic acne, that's a very long post, trust me. The quick end is Loren Cordain wrote a very short book call the the dietary cure for acne, and it's spot on in explaining the hormonal roller coaster we are all on) you name it. This has been going on for more than 25 years. Before my wedding in OCt I tripped upon another website for acne and there were some people having great succes with good ole BP and salycilic acid. The catch is in the application. I tried every bp product in the world till this point and they didin't work, but now I use it a little differently. I use an SA wash by OXY and then the OXY wash with 10% BP as a mask for 10-15 min in the morning and at night. The results have been great. Don't be afraid of moisturizer, i know us acne suff. tend to dry our skin out to no end, but use an oil free moisturizer, cause you will get dry. I still get an occasional bugger around by period, but they resolve at some point. IN the past I needed to get cortizone injections they were so deep and inflamed. My best guess is that when bp is not layered on very thickly and given the appropriate amount of time to work, some of us have too stubborn bacteria or too much and it's not effective. THis allows the med to work longer. All I can say is I've been able to control mine to where my life is no longer on hold. I also avoid refined sugar, I use stevia or xylitol to sweeten everything i make myself and i use splenda or other diet products when i'm out. I hate to use the latter because i'm not convinced they're healthy but i crave a diet coke with food sometimes. eating better will definitely help to some extent and dr perricone in his book the the clear skin prescription talks about coffee both reg and decaf having an effect on the adrenal glands which ultimately effects testosterone, etc to have the effect on acne. Sorry this is so lengthy and sloppy, but i knew i hadn't been doing my part to help the cause. good luck.