Discussions that mention aciphex

Colds & Flu board


You have the CLASSIC symptoms of laryngopharyngeal reflux (LPR), which is a form of GERD (gastro-esophogeal reflux). Basically, the acid in your stomach is refluxing all the way into your throat. I have NO DOUBT based on your description that you have LPR.

I know this is what you have because sensation of "lump in the throat" plus "chronic cough" are 2 classic symptoms of LPR.

So you need to go and visit the Acid Reflux message board. Then you need to get to an ENT and Gastroenterologist in your closest metropolitan city. Small-town docs and suburban docs don't see enough LPR to make heads or tails of it. Pick a teaching hospital in an urban area.

If you are in Maryland, Delaware, NJ, NY, or CT, please see the sticky on the top of the Acid Reflux board for some doctor names. Otherwise, purchase a Castle Connely list of best doctors for your area.

You need to see an ENT to "get scoped", and you need a gastro to do an endoscopy.

You also can hopefully relieve your symptoms by taking 2 doses of a max-strength proton pump inhibitor each day (PPI).

For instance, you can take Nexium, Prilosec Brand, Aciphex, or Zegerid, 2x per day.

This should help your symptoms significantly. In best case scenarios, they will completely relive the problem. Sometimes they relieve it to a degree./
Wow! What a reply! I guess that by now you've gone and independently researched "laryngopharyngeal reflux", if not - please do. There's loads of information on the internet about it.

Since you live in the UK, you need to be aware that the medications I listed are typically sold under different brand names than in the U.S. You might want to figure out those brand names before you go to a doctor. Since you think that LPR is a distinct possibility, I also want to recommend that you start with the PPI called Nexium (don't know the UK equivalent name, or if there is one).

Nexium, time and time again, becomes the PPI of choice for people with LPR. I don't know why exactly, it has a slight structural difference, but it should be the first (and hopefully last) PPI that you try in treating this condition. You will need to immediately begin taking 2 doses of the 40 mg Nexium every day. I highly recommend taking the 2 doses together first thing in the morning. If after 30 days no improvement, then switch to one in the morning and one in the evening. One thing you will learn is that everyone responds somewhat differently to the meds and timing of the meds, so you may need to experiment. Should meds ultimately fail or be inadequate, there are surgical options to explore. Still, the Nexium 2x per day is the best way to start. Beware - most doctors (at least in the US) have relationships with pharma sales people and these relationships affect which drugs they prescribe to their patients. You may need to be highly vocal about insisting on Nexium. Because if the Dr likes the Aciphex rep better, then he's gonna fight you on it. But hopefully you'll see a top top doctor in the UK - and here's one to go to who "gets it": My doctor is one of the leading authoritieis on LPR in the U.S. and his co-author on his latest book is from England. Perhaps you can contact him - John Rubin. I pulled the following quote from one of my old posts:

"I learned that this doctor, Robert Sataloff (the head of the practice I go to in Philadelphia) just published the latest edition titled "Diagnosis and Treatment of Voice Disorders" in May 2006 and his co-author is John Rubin, M.D., from the U.K. Sounds like he is the go-to guy in your country for this stuff, and maybe if you can't visit him, perhaps his practice can point you in the right direction locally."

John S. Rubin, M.D., is a Consultant Ear Nose and Throat Surgeon at The Royal National Throat Nose and Ear Hospital Division of The Royal Free NHS Trust, where he is the Lead Clinician of the Voice Disorders Unit as well as Clinical Director. He is also a Consultant ENT Surgeon at St. Bartholomew's Hospital, Honorary Senior Lecturer at University College London and Visiting Associate Professor at The Albert Einstein College of Medicine in New York.

I also pulled the following from another of my old posts at the acid reflux board. I believe the article I reference is available online if you search for it:

"Hi everyone, On May 16th, 2006, the publication GI Motility Online published an exhaustive article titled "Laryngeal and pharyngeal complications of gastroesophageal reflux disease", written by regory N. Postma, M.D. and Stacey L. Halum, M.D.This is the most complete and exhautive article detailing LPR I have ever read. Given it's publication date, it is also up-to-date. Read it while it's still available. I was very pleased to see how it categorized LPR into different states - minor, major, and life-threatening. The authors truly recognize the differences between GERD and LPR and go as far as to say they are related, but unique entities, and LPR can be further segmented by severity. It also discusses treatment for each level of LPR.
I think this is the article that you've been dreaming about - to give to your friends and family so they really understand what you are going through with this nasty disease."

Andrew - you are so young to be going through this, I really do feel for you. I was 28 when I was diagnosed 4 years ago, and I really thought my world was about to end. But about 85% of us with LPR get very good results with pharma/surgical management. I pray that you are one of those!