Benadryl is a good over the counter drug for allergies. I do not know if it mixes with reflux drugs or not. You should check that out. I take Zyrtec and have good luck with it for allergies, and it is ok to take with the aciphex that I take for reflux. When you say that things are worse at night, to you mean in general or after you go to bed? Reflux tends to be more bothersome when you are lying down.