Discussions that mention ansaid

Allergies board

Hi, all. Please bear with me...this is long. :)

About 19 years ago, I suffered a disabling knee injury, while in the Navy, that never fully resolved. For nearly 2 years, between the injury and a discharge due to the disability, I was treated heavily with NSAIDS, including Motrin (up to 800 mg t.i.d), Naproxin, Ansaid, and finally Tolectin. I was continued on Tolectin DS 400 mg b.i.d PRN. After several relatively pain-free months, I took a low-dose Motrin. About four hours later, I started to experience a mild allergic reaction, controlled by 25 or 50 mg of Benadryl. I had no previous history of allergies, and during that four-hour window, I had managed to eat chocolate, nuts, and shellfish, none of which had ever caused a reaction, but the Motrin never even occurred to me.

A couple of months later, I needed a Tolectin, and before the capsule would have had time to dissolve significantly, literally within less than 3 minutes, I started experiencing severe itching on the palms of my hands and soles of my feet, followed very rapidly by vomiting, brief loss of consciousness, airway constriction, altered hearing and loss of peripheral vision. I worked as a 911 operator/dispatcher for the city in which I lived, so I at least had the comfort of knowing and trusting the paramedics who worked me at the scene and transported me. I was somewhat conscious in the ambulance and was able to talk despite difficulty breathing. The medic said my BP was 60/40, and he had never seen anyone with such a low BP carry on a conversation. I remember his telling me that if it dropped lower or I lost consciousness, he would have to start an IV while en route. I've never been afraid of needles, but the ride seemed so unbelievably bumpy that I had this sudden fear of arriving at the ER with an IV...and track marks. I don't know whether to attribute it to sheer force of will, but I somehow managed to stay conscious until we got to the ER. I think if he hadn't known me well enough to have a better awareness of my status and degree of orientation than he would have with a stranger, I'd have arrived intubated and with an IV. :)

Two questions:

Is it unusual for people to develop, apparently out of nowhere, an allergy to medications they have been taking for years?

I have two children. As infants, both have had mild illnesses with fever, for which the pediatrician recommended alternating Tylenol and Motrin. The pediatrician said that my having developed the NSAID allergy as an adult did not increase the chance that either of them would have any problem with Motrin, and neither of them has. What their pediatrician couldn't tell me, and neither has any other physician, is whether I might have a reaction to the metabolites of the Motrin if I came in contact with their bodily fluids*. Does anyone have any experience, references, etc., that might shed some light on that?

*As a father, I have always taken a tiny bit of pride in the fact that I have never gotten peed on during a diaper change. Growing up male, there are some things a father just knows, especially with a newborn son. Mommy would change his diaper as soon as he woke up from a nap. Daddy waited a few minutes, THEN changed the diaper. No worries. As for my daughter, I guess it was just a mix of my dumb luck and her inability to aim. :D