Your hypothesis or theories on the connection(s) between ARBs and angina are a brain teaser (not much of that left to tease here though, lol). Very interesting....We need you on the FDA payoff advisory board. OOps the Pharm Police may read this.... :nono:
I figure some that read my post about Atacand and angina, may doubt whether I know what angina really is. I know that would be the first doubt that I would have had, if someone else had posted likewise. 2 of my 4 stents caused angina, as the balloon was pressurized to deploy the stents. The doc even warned me before hand that the balloon inflation time would cause blood flow to my heart to stop. WOW, it did and the doc said, "have you ever felt this at home?" I struggled to say YES! So I do know what angina the monster is.
To my knowledge (ha ha ha) I only know of 2 things that can cause angina; one is a blockage in coronary artery blood flow and the other is coronary artery spasms which momentarily stop the blood flow. Usually a spasm is associated with a blockage, but not always (I have read). Could the ACEs and ARBs, or just the ARBs cause a spasm, by way of what you mentioned? Could the cells of the lining of some's arteries be "goosed" by the ARB, when the angio receptor cells are blocked, leading to a spasm?
I have also thunk about the cytochromes involved with the metabolism of ARBs vs the statins. CYP 450 metabolizes Lipitor.
CYP 450 Interactions: The enzyme(s) responsible for valsartan metabolism have not been identified but do not seem to be CYP 450 isozymes. The inhibitory or induction potential of valsartan on CYP 450 is also unknown.
An iron-containing protein found in the mitochondria of eukaryotic cells; each is given a letter name (a, b, c). The cytochrome transport system (electron transport chain) is the last stage in aerobic cell respiration)
I used Diovan (valsartan) above, but the same is written about Atacand. Enough of dis. My head is spinning :confused:
Hey those caths are one big piece of cake! You know, they always prepare both groins (both sides?) to be entered but have only used my right one, 8 times (can't they spin those tables?). The doc said that he would have a little problem deadening the insertion area, due to scar tissue from my previous caths (I can't see any scars). Still, the humpteen shots he gave me there, didn't hurt as much as when the iv was inserted into my hand (bone, lol). I never felt the tiny incision, or the insertion of the sheath....You also know that we have no feeling within our arteries or veins.
Still the risks are what we worry about. Hey, if these country fellows haven't caused me to croak yet, I'm sure your docs will do just fine. The cutting tool head did come apart during rotoblational arthectomy, when they flushed the debris with water. The professor took control and retrieved it though. I was on the table for 1.75 hours. This procedure is rarely used. I had a choice of CABG or this deal. No choice there for me :)
I remember you mentioning angina. There is nothing like a clean whistle, or cleaning one out, to make one feel sooo much better. Mine only play E, A,C and G. What chord is that? (House of the Rising Sun)
Thanks for your information and hang tough....