Discussions that mention atacand

High & Low Blood Pressure board


Lenin, I found the information you were interested in, in the prescribing info (PDF) under "post marketing experience". Just do a search on "atacand" and go to the company website.
This is what I came up with , any comments ???

Other potentially important adverse events that have been reported, whether or not attributed to treatment, with an incidence of 0.5% or greater from the 3260 patients worldwide treated in clinical trials with ATACAND are listed below. It cannot be determined whether these events were causally related to ATACAND. Body as a Whole: asthenia, fever; Central and Peripheral Nervous System: paresthesia, vertigo; Gastrointestinal System Disorder: dyspepsia, gastroenteritis; Heart Rate and Rhythm Disorders: tachycardia, palpitation; Metabolic and Nutritional Disorders: creatine phosphokinase increased, hyperglycemia, hypertriglyceridemia, hyperuricemia; Musculoskeletal System Disorders: myalgia; Platelet/Bleeding-Clotting Disorders: epistaxis; Psychiatric Disorders: anxiety, depression, somnolence; Respiratory System Disorders: dyspnea; Skin and Appendages Disorders: rash, sweating increased; Urinary System Disorders: hematuria.

Other reported events seen less frequently included angina pectoris, myocardial infarction, and angioedema.

Adverse events occurred at about the same rates in men and women, older and younger patients, and black and non-black patients.

Heart Failure

The adverse event profile of ATACAND in heart failure patients was consistent with the pharmacology of the drug and the health status of the patients. In the CHARM program, comparing ATACAND in total daily doses up to 32 mg once daily (n=3803) with placebo (n=3796), 21.0% of ATACAND patients discontinued for adverse events vs. 16.1% of placebo patients.

Post-Marketing Experience

The following have been very rarely reported in post-marketing experience:

Digestive
Abnormal hepatic function and hepatitis.

Hematologic
Neutropenia, leukopenia, and agranulocytosis.

Metabolic and Nutritional Disorders
hyperkalemia, hyponatremia.

Renal
renal impairment, renal failure.

Skin and Appendages Disorders
Pruritus and urticaria.

Rare reports of rhabdomyolysis have been reported in patients receiving angiotensin II receptor blockers.
I feel like I have been run over by a train, so I stopped Atacand last night (after almost a month). I think my problems are coronary artery blockages (again), probably, but I would love it if my chest pain is being caused by this medicine, AND IT WOULD STOP!
Well Lenin and all, I got my 8th cardiac cath yesterday and I am clear as a whistle :) My doc was on vacation, so I drove over to see one of his partners. The nurse I spoke with, and that set the appointment up, said they would rather me go to the ER but that they could get me into the hospital and bypass the ER. The doc there said what are you doing here? Well to make a long story longer :) I drove straight to the hospital outpatient facility.

I told the doc when I got there (not the hospital) that I suspected Atacand. He was dubious. I told him that the aches, pains and angina had improved 100%, and I had skipped Atacand the night before, and was going to forever skip it...I told him after a warm shower whilst preparing to come to see him, I really started to feel better. He said that a warm shower would not stop angina. I sad that I was fully #$%&&% aware of that.

The cath doc had heard of bad reactions to Atacand. He tended to think that some people couldn't tolerate ARBs, as a class of medicine. He asked if I had ever tried Diovon. I said no, but if I was going to take another BP medicine, I wanted the ones that screwed with angiotension in some way because of the protection against heart failure. He wants me to come by his office to get some different samples of ARBs.

So I think that I am in that small percentage that can develop angina from either Atacand or ARBs in general. I do wonder about statins and ARBs now. As I reflect on the pain from Atacand and the pain from statins when I tried them, it seems very similar except for the angina, which statins never caused.
Viper,

I am not sure that whatever causes this adverse reaction with Atacand, would show on any test. It probably wouldn't hurt though if you have to continue this medicine. I used to take Coq-10 daily. even though I cannot take statins. I stopped taking supplements everyday. I only take them occasionally. If I were taking statins, I would spend the money for the best Coq-10 and take it daily. Are you taking any medicine to lower your cholesterol? I have even tried Zetia, which is not a statin, and it caused musle pain and flu like symptoms in me. It also carries the same warnings as the statins, which amazed me.
Lenin,

Your hypothesis or theories on the connection(s) between ARBs and angina are a brain teaser (not much of that left to tease here though, lol). Very interesting....We need you on the FDA payoff advisory board. OOps the Pharm Police may read this.... :nono:

I figure some that read my post about Atacand and angina, may doubt whether I know what angina really is. I know that would be the first doubt that I would have had, if someone else had posted likewise. 2 of my 4 stents caused angina, as the balloon was pressurized to deploy the stents. The doc even warned me before hand that the balloon inflation time would cause blood flow to my heart to stop. WOW, it did and the doc said, "have you ever felt this at home?" I struggled to say YES! So I do know what angina the monster is.

To my knowledge (ha ha ha) I only know of 2 things that can cause angina; one is a blockage in coronary artery blood flow and the other is coronary artery spasms which momentarily stop the blood flow. Usually a spasm is associated with a blockage, but not always (I have read). Could the ACEs and ARBs, or just the ARBs cause a spasm, by way of what you mentioned? Could the cells of the lining of some's arteries be "goosed" by the ARB, when the angio receptor cells are blocked, leading to a spasm?

I have also thunk about the cytochromes involved with the metabolism of ARBs vs the statins. CYP 450 metabolizes Lipitor.

CYP 450 Interactions: The enzyme(s) responsible for valsartan metabolism have not been identified but do not seem to be CYP 450 isozymes. The inhibitory or induction potential of valsartan on CYP 450 is also unknown.

(cytochrome
An iron-containing protein found in the mitochondria of eukaryotic cells; each is given a letter name (a, b, c). The cytochrome transport system (electron transport chain) is the last stage in aerobic cell respiration)

I used Diovan (valsartan) above, but the same is written about Atacand. Enough of dis. My head is spinning :confused:

Hey those caths are one big piece of cake! You know, they always prepare both groins (both sides?) to be entered but have only used my right one, 8 times (can't they spin those tables?). The doc said that he would have a little problem deadening the insertion area, due to scar tissue from my previous caths (I can't see any scars). Still, the humpteen shots he gave me there, didn't hurt as much as when the iv was inserted into my hand (bone, lol). I never felt the tiny incision, or the insertion of the sheath....You also know that we have no feeling within our arteries or veins.

Still the risks are what we worry about. Hey, if these country fellows haven't caused me to croak yet, I'm sure your docs will do just fine. The cutting tool head did come apart during rotoblational arthectomy, when they flushed the debris with water. The professor took control and retrieved it though. I was on the table for 1.75 hours. This procedure is rarely used. I had a choice of CABG or this deal. No choice there for me :)

I remember you mentioning angina. There is nothing like a clean whistle, or cleaning one out, to make one feel sooo much better. Mine only play E, A,C and G. What chord is that? (House of the Rising Sun)

Thanks for your information and hang tough....