I know I didnt seem to have any health problems until I put on weight. So I KNOW extra weight can cause all sorts of problems. But then again the weight came on with turning 40 so maybe thats it too. Ugh. I am on atenolol 50 mg a day and I know that, that slows your heart rate thus reducing your metabolism and making losing weight a very difficult process. Keep trying my friend, I joined the gym recently and started out with water aerobics... that was a fun day. lol maybe I'll go back one of these days. Anyway I wish you the best and dont give up!