Im currently taking 10mg's 4 times a day, and so far I think they have worked great, because after eating a decent meal before, I would get stomach cramps so bad, that it would bring me to my knees, and I'm a big guy. The cramps were so intense that I would vomit from the pain. I take them a half hour to 45 minutes before I'm going to eat, and I haven't had any cramps at all yet since starting them. I also suffer from major constipation as well, so I don't want to get severely backed up either. Because the side effect said that there can be constipation, and I felt un easy about that, plus I have to watch out because I'm on Reglan too, and they are the opposite of Bentyl.