My son has been taking its generic, minocin, for about 5 1/2 weeks ( 100mg twice a day). He is also applying benzaclin, and using a bp wash twice daily. He has severe acne, but it has been drying up some. The derm said it would take the minocin about 2 months to really show any effect. They said it should help with the cysts. They also said that they switch antibiotics about every 6 months so the patients wouldn't become immune to them. I hope it works for everyone!!