My son has been using it with minocycline for about 2 months. He's just started using retin-a micro at night and only using the benzaclin in the A.M. He has seen some clearing and the derm said that lots of times noticeable clearing doesn't happen until after the 2 month mark. I just hope the RAM doesn't cause a lot of initial breaking out! Then we won't know what's working and what's not! I hope he can go off the antibiotic and just stay on the benzaclin and RAM. Time will tell. It's good to hear that something he's using has had good results on someone else!