Discussions that mention celebrex

Pain Management board


Hello friends,

I was directed to a neurosurgeon by the doctor who has been treating me for arthritis and fibromyalgia. The pain I've been having is increasing in intensity and the medications I'm on are not working very well. The meds are:

Remicade infusions, weekly Methotrexate shots, Celebrex,
Neurontin, Hydrocodone-10, and a Duragesic 25 patch.

The surgeon examined me and studied the MRI's, x-rays, and the results of a CT Myleogram, which indicated "broad-based" bulging of 2-3 discs in my neck and 2-3 discs in my lumbar area. He told me that surgery was not indicated as no blockage of nerves was revealed. The discs are simply deteriating and pulling on the discs.

He told me that he thought that I was on too many medications. He said that some meds were preventing receptors from being able to take advantage of the pain meds. His opinion is that I should be weaned off some of the meds, under supervision, and then possibly try some different pain meds.

Has anyone had an experience like this? I've never heard of too much medication preventing pain meds from working properly. I would appreciate any help. Thanks !!
I typed all of your meds into an on-line drug ineraction checker.

The following came up-

Fentanyl (Duragesic) it says don't drink Grapefruit juice while you are on Duragesic.

Remicade and Methotrexate together may make you more suseptable to getting an infection because they supress the immune system.

Hydrocodone, Neurontin, and Duragesic all work as CNS (central nervous system) depressants... (according to the medical mumbo-jumbo you are fine as long as you are breathing ok) from what I understand, if you are at MUCH higher doses of these 3 meds together, it can effect your breathing rate, but at your dosages you are OK.


Hydrocodone and Celebrex together had something that I didn't really understand... I copied it here....

Moderate Interaction -- Drug-Drug
hydrocodone and celecoxib (Celebrex)

MONITOR: The coadministration of celecoxib and drugs that are substrates of the CYP450 2D6 enzymatic pathway may result in elevated plasma concentrations of those drugs. The mechanism is decreased clearance due to inhibition of CYP450 2D6 activity by celecoxib. MANAGEMENT: Caution is advised if celecoxib must be used concurrently with medications that undergo metabolism by CYP450 2D6, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever celecoxib is added to or withdrawn from therapy.

I think that the above means that taking the Celebrex and Hydrocodone together can make each of them stronger?? or eack of them weaker maybe?? I am not completely sure...


As far as I can tell there is no really serious problems... especially since the site I used will highlight severe problems in red, and there were no red warnings when I type in all of your meds together.

Your doc may just want you to use medications that will work better together, or maybe even a totally different med that will do the same thing as 2 of your current meds do combined so that you take less pills... or maybe he knows of an entirely different medication combo that will work a whole lot better for your set of problems.

It sounds to me as if he wants you to get the best pain relief and symptom relief that you are able to get...

I hope that the above info helps...

~Wittesea
Quote from Wittesea:
I typed all of your meds into an on-line drug ineraction checker.

The following came up-

Fentanyl (Duragesic) it says don't drink Grapefruit juice while you are on Duragesic.

Remicade and Methotrexate together may make you more suseptable to getting an infection because they supress the immune system.

Hydrocodone, Neurontin, and Duragesic all work as CNS (central nervous system) depressants... (according to the medical mumbo-jumbo you are fine as long as you are breathing ok) from what I understand, if you are at MUCH higher doses of these 3 meds together, it can effect your breathing rate, but at your dosages you are OK.


Hydrocodone and Celebrex together had something that I didn't really understand... I copied it here....

Moderate Interaction -- Drug-Drug
hydrocodone and celecoxib (Celebrex)

MONITOR: The coadministration of celecoxib and drugs that are substrates of the CYP450 2D6 enzymatic pathway may result in elevated plasma concentrations of those drugs. The mechanism is decreased clearance due to inhibition of CYP450 2D6 activity by celecoxib. MANAGEMENT: Caution is advised if celecoxib must be used concurrently with medications that undergo metabolism by CYP450 2D6, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever celecoxib is added to or withdrawn from therapy.

I think that the above means that taking the Celebrex and Hydrocodone together can make each of them stronger?? or eack of them weaker maybe?? I am not completely sure...


As far as I can tell there is no really serious problems... especially since the site I used will highlight severe problems in red, and there were no red warnings when I type in all of your meds together.

Your doc may just want you to use medications that will work better together, or maybe even a totally different med that will do the same thing as 2 of your current meds do combined so that you take less pills... or maybe he knows of an entirely different medication combo that will work a whole lot better for your set of problems.

It sounds to me as if he wants you to get the best pain relief and symptom relief that you are able to get...

I hope that the above info helps...

~Wittesea


I happen to be surfing the boards and really was thrilled to know that their is a website for us to check drug interactions. Can you share that with us.

Thanks
Lisa