I was diagnosed with PMDD and in Nov of 2002 I had a hysterectomy. They put me on Cenestin and I stayed on it for about a year. In that year I gained almost 40 pounds and was very depressed. About 3 months ago I stopped taking it all together and lost about 18 lbs. My problem is even tho I'm losing weight, I'm miserable. I'm having hot flashes real bad, depression, anxiety, I have a hard time concentrating on anything, especially reading. Is there any hrt's out there that won't cause the weight gain, but will help with the rest.