Discussions that mention cimetidine

Pain Management board


pdawg,

I found some more info about codeine you might be interested in. I only remembered part of what I had read about it.

Codeine is both a direct analgesic, weakly binding mu receptors, and a prodrug. It is converted into morphine in the liver. Patients deficient in a converting enzyme, CYP2D6 (10% of the population) or those taking inhibitors of this enzyme, (examples are quinidine, cimetidine and fluoxetine), may not achieve analgesia because of an inability to convert codeine to morphine.

Could be you are in that 10% population or taking one of the drugs that interfers with the codeine.

Does that help?
Carol