I'm prone to those big ones - nasty ones they are. Anyway - what I do is increase my Akamin/minocyline (antibiotic) tablets to X3 per day, on the pimple I treat with my clindamycin as per usual + add toothpaste and cover with a bandaid - during the day if possible and always at night time. Seriously, it works for me. Occasionally I have tried an ice pack - seems to decrease the swelling. Oh and rule #1 don't squeeze - it's tempting, I know but will only make it worse and increase the likelihood of another pimple developing.