Discussions that mention clindamycin

Acne board


I have been using Clindamycin topical solution as well as taking oral clindamycin for quite a while now. On and off for 4 years or so. It used to work but now I think I'm resistant to it because now instead of being on the surface, my acne is mainly cystic and sometimes I get huge cysts that won't come to the surface for about a month and when they do they have like 2 or 3 giant white heads.
So I recently added Differin to the mix. I'm using the clindamycin topical twice daily and the differin at night over it (after it dries of course).
Right when I started the differin i had the usual drying and peeling and right after that i thought i was noticing improvement with just little patches clearing up at a time. I have now been using it for 1.5 months now and about 1/2 of my left cheek is completely clear and smooth. The rest of my pimples appear in groups now even though I don't seem to get quite as many scattered all over my face like I used to.
But... The pimples that I do get are much larger than the ones I would get before starting differin. They also seem deeper under the skin. They are also much harder to pop and have bigger whiteheads.
Did anyone else experience anything like this and if so was it just a phase of the differin? That little patch of clearing gives me hope but the rest don't seem to go away. They just sort of relocate. I don't know if I want to continue using it if this keeps up for much longer. I would appreciate any advice.