Discussions that mention clindamycin

Acne board


I would recommend going on Differin immediately because you will continue with the retinoid treatment you are doing now and I have found it is just as effective. I've been on Tazorac, Stieva-A (Tretinoin) and Adapalene (Differin) is as effective with less irritation. = MAJOR BONUS.. I was in an acne flare for the first week and then after the week no more new ones were developing and it was just the red marks that had to heal and the medication in the first month seems to highlight all your previous and present leasion healing. But, in the long run this product will keep your pores clear. It takes time for your pores to clog (hence 1-3 months for a lesion to fully develop) It will take that much time to clean them out. I hope someone reads this and it makes a difference with them. For most people what you eat doesn't matter (why do some people I know eat like crap and have perfect skin). So excessive vitamins and all that are no good either. And it doesn't matter how much you wash your face (good to prevent white heads (surface acne) but nothing else.. Acne is a trait we are born with. It's a disorder of out pores. It's common sense here. People with different grades need different treaments.. For mild to Moderate I would highly recommend Differin. Just deal with the worst couple weeks and it's easy as cake from there.

Here's a scientific Medical Journal Entry based on a trial test in comparison of other related products (Just copy and pasted from a Med. Journal site and didn't happen to grab the title of the site - sorry)

Adapalene : a review of its use in the treatment of acne vulgaris.
Waugh J, Noble S, Scott LJ.

Adis International Limited, Auckland, New Zealand.

Adapalene (Differin((R))) is a retinoid agent indicated for the topical treatment of acne vulgaris. In clinical trials, 0.1% adapalene gel has proved to be effective in this indication and was as effective as 0.025% tretinoin gel, 0.1% tretinoin microsphere gel, 0.05% tretinoin cream and 0.1% tazarotene gel once every two days; however, the drug was less effective than once-daily 0.1% tazarotene gel. It can be used alone in mild acne or in combination with antimicrobials in inflammatory acne and has proved efficacious as maintenance treatment. Adapalene has a rapid onset of action and a particularly favourable tolerability profile compared with other retinoids. These attributes can potentially promote patient compliance, an important factor in treatment success. Adapalene is, therefore, assured of a role in the first-line treatment of acne vulgaris.Pharmacological PropertiesAdapalene is a chemically stable derivative of naphthoic acid that binds selectively to the nuclear retinoic acid receptor (RAR) subtypes RARgamma (found mainly in the epidermis) and RARbeta (found in dermal fibroblasts), activating genes responsible for cellular differentiation; it does not bind to cytosolic retinoic acid binding proteins. Adapalene is thought to modulate keratinisation, differentiation and inflammation of follicular epithelial cells. This results in a reduction in microcomedones, the precursors of acne lesions.Absorption of 0.1% adapalene gel through human skin is low. Adapalene was not detected in plasma in volunteers after topical application of either the gel or cream, nor was it detected in urine, faeces or skin. In animals, metabolism is via O-demethylation, hydroxylation and conjugation, and excretion is primarily by the biliary route. There are no known interactions with other drugs and, because of the low absorption through the skin, interaction with systemic drugs is unlikely.Therapeutic EfficacyAcross several endpoints (including the mean percentage reduction in the number of inflammatory and noninflammatory lesions), 0.1% adapalene gel had similar efficacy to 0.025% tretinoin gel, 0.05% tretinoin cream and 0.05% isotretinoin cream as well as the newer 0.1% tretinoin microsphere gel formulation in the treatment of mild-to-moderate acne vulgaris. Data were from predominantly multicentre, randomised, single- or double-blind, parallel-group trials. After 8-12 weeks' treatment, the percentage reductions in lesion counts were 47-75% and 38-73% for adapalene and 0.025% tretinoin gel treatment groups (inflammatory lesions), respectively, and 46-83% and 33%-83% (noninflammatory lesions). The similar efficacy of these two treatments was confirmed by two meta-analyses. The onset of action with 0.1% adapalene gel is rapid and generally appears to be similar to that with tretinoin formulations.In two randomised, double-blind, parallel-group studies, patients with mild-to-moderate acne vulgaris receiving 0.1% tazarotene gel once daily had significantly greater reductions in inflammatory and noninflammatory lesions than 0.1% adapalene recipients. The same dosage of 0.1% adapalene gel showed similar efficacy to that of 0.1% tazarotene gel once every two days (dosage reduced to improve tolerability) in another trial of the same design.Data indicate that 0.1% adapalene gel is effective in combination with topical clindamycin or benzoyl peroxide or oral cyclines (lymecycline, minocycline) in reducing the number of inflammatory and noninflammatory lesions in patients with mild-to-moderate or moderate to moderately severe acne vulgaris. Furthermore, 0.1% adapalene gel was effective as maintenance treatment following treatment with clindamycin plus adapalene.TolerabilityAdapalene was generally better tolerated than comparators, particularly in the first 4 weeks of treatment. The most commonly reported adverse events in both adapalene and comparator recipients were erythema, dry skin, pruritus, desquamation and stinging/burning sensations. These were generally less severe in adapalene recipients than in the recipients of other topical retinoidn the recipients of other topical retinoids.Several randomised, intraindividual patch studies in healthy volunteers found 0.1% adapalene gel was the least irritating acne treatment when compared with various concentrations of tretinoin gel, cream, the new formulation of tretinoin (0.1% and 0.04% tretinoin microsphere gel) or with tazarotene gel.When used as adjunctive therapy with topical clindamycin or oral lymecycline, 0.1% adapalene gel was generally well tolerated compared with gel vehicle plus the respective antibacterial agent. Overall, local cutaneous adverse events were mild in intensity.

Point Blank (if you've read this far and if you have I hope you really listen here) This product works all out for real... Observing the beginning days of treatment I noticed my skin was oilier for the first few days due to excess oil seeming to be 'pushed out'. Also, during this period I noticed a distinct sulphur related smell when I was splashing warm-hot water on it before washing with a soap free bar. So my regime consisted of this

Before Bedtime - Wash face with mild soapless face bar (neotrogena, dove sensitive skin) After patting face dry I apply thin film of Differin to affected areas.

Morning - Wash face with soapless bar and apply Benoxl 10% Benzoyl Peroxide in thin film over face for an hour or two and wash again with mild soapless bar. Skin didn't seem to irritate due to the mildness of the bar.. Cleaner skin seemed to make me feel less of the symptoms. I didn't want to leave the benzoyl peroxide on all day to prevent excessive redness but just enough to get the effectivness of the antibacterial properties. I notice I didn't have that smell on my face no longer and my skin was dryer. But, good dry..

If you have made it this far and read this. get back to me.. this treatment works! I'm a strong believer the next few months will be a breeze.. I haven't gotten any more new lesions after the beginning flare. Like an immediate response. Like I said, just deal with the beginning 'bad' stage.