I ws taking Minocycline when I started taking Spiro. After about a month or two though, I stopped the Mino because it seemed as though the Spiro was working well. My doctor did not mention any problems with taking an antibiotic + spiro together, and I've read other stories of women taking both together. Spiro can often take 3-6 months to really work. IMO, an antibiotic is the perfect thing to take in the meantime to get you through this waiting period. If you don't like the idea of taking an oral antibiotic, you could also try a topical one like clindamycin. starting something like retin-a right now is also something to consider (it's got great skin benefits!), but with this there will most likely be an initial breakout. good luck!