I don't have AS, I have psoriatic arthritis, but I've been on the methotrexate, and prednisone, and sulfasalizine, and, remicade, and you name it. One thing that changed my life was Enbrel. It works so well for me. I have been able to stop the prednisone completely for a couple of years now,( I've been on the Enbrel for about 3.) Enbrel is the best thing that ever happened to me, fewer flareups, less pain and stiffness, and I found it to have fewer side effects than most of the meds I've been on. I am now maintained on plaquenil, clinoril, and enbrel. I do get infections easily, but I get them treated promptly and haven't had any serious trouble. The only other side effect for me was injection site reaction which went away within a few weeks of using the medication. I have an aunt with AS who is also unsure about whether or not to try Enbrel and I told her to go for it. I hope this will reassure people out there who are afraid to give it a shot. It has been a lifesaver.