Discussions that mention comtan

Parkinson's Disease board


Azilect (Rasagiline) is a once-daily product and one of the few treatment
options in the U.S. indicated for all stages of PD. It is an irrerversible monoamiine oxidase (MAO) type B inhibitor.
A potentially life-threatening adverse drug reaction that may occure following it's use and is called Serotonin syndrome, or serotonin toxicity, or "cheese reaction," and is due to excessive amounts of serotonin in the CNS. Although, Azilect generally does not cause such reactions in therapeutic
PD doses. It is recommended that patients avoid foods (sharp cheeses) and
red wines containing amines such as tyramine. Also, it is not recommended
to be taken with Selective Serotonin Reuptake Inhibitors (SSRI,s), tricyclic
antidepressants, amphetamines, cocaine, demerol (meperidine) and the
list goes on and on.
By inhibiting MAO-B, Azilect prevents the metabolism of dopamine, thereby
increasing the concentration in the synapse.
Another enzyme (cathechol-o-mthyltransferase [COMP])that metabolizes the precursor (levodopa) to dopamine is entacapone (Comtan).

John g
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