The beta blockers and Clonidine were invented in 1974. As far as I know no BP meds that lower heart rate have been made since. I have a friend who is having a terrible time lowering his blood pressure. He was given 100mg of Cozaar today, and is hoping that is going to work. For some reason the Lisinopril isn't working anymore. My question is: do the heart-rate lowering drugs (beta blockers & Clonidine) usually work better than the ACES and ARBS? I'm thinking they might, because why are they still prescribed after 32 years when there are ACES & ARBs with less side effects. Please let me know your opinions. Thanks.