Starr - I wish I could give you some input about the pills, I had a colonoscopy 4 years ago, and I had to drink 2 bottles of liquid - at different times. You should follow the times your doctor gave you. It doesn't take long for the prep. to start working. I'm not going to tell you it's fun, but you must be completely cleaned out, or they won't be able to do the test. Are you going to be sedated? I was given valium and demerol, but I didn't fall asleep like my husband did. I was a bit groggy and I watched some of it on the screen. I had no pain. I remember saying to the doctor - "why isn't my colon as nice as Katie Couric's ??!!! Don't worry, you'll be fine - it's just fear of the unknown. Next year I have to go back and have another one. Better safe than sorry.