Discussions that mention demerol

Pain Management board

The two natural alkaloids used directly for PM that issue from opium are codeine and morphine. The other major alkaloid is thebaine, but this is synthesized before use in PM. So, codeine and morphine are opiates.

Pretty much, the remainder are opioids, either partially or fully synthetic. Examples of partial synthetics would be hydrocodone (Vicodin), Hydromorphone (Dilaudid), oxycodone (OxyContin) and such. Examples of fully synthetic opioids would be Methadone and Ultram. I believe that Demerol is also fully synthetic, but I'm not positive. Of course, there are other examples but hopefully these will do.

An opioid is a synthetic opiate. An opiate would be like morphine, heroin or codeine that requires one or more of the derivetives of natural opium.

Codeine is notoriously harsh on the stomach and so is morphine and heroin, it's also notoriously sedating which does get better with time. The synthtics are the meds in The keto synthetic family, Hydrocodone, oxycododne, hydromorphone and oxymorphonne, The fents and demerol are also synthetic ans so are meds like methadone or levordromoran.

Actually no raw opium is needed to manufacturer opiates since the discovery of opiate synthesis in "79. However the drugs created after the natural model still have the harsher side effect profile and take longer to get used too as their older versions that contained an opium extract. Therefore, the negative aspect is very present with each dose increase.

In thoery more pain can be managed with less side effects using a synthetic with a milder side effect profile. Of course there will be exceptions, but this is the general rule. For example a couple tylenol 3 "an opiate/natural" will have my guts in knots 30 minutes after taking it, where 10 times the dose of oxycodone doesn't bother my stomach at all. If you remove the harsheness, a higher dose can be taken without the nasty side effects. This makes it more popular with severe CP and with people looking to abuse or use it recreatonally.

So it makes sense to see faster tolerance to oxycontin if the side effects are easier to manage. Titration would be longer and more unpleaeant if you have to wait for the nausea and sedation to deminish before increasing a dose of morphine.

Take care, Dave
"Opiate" refers to alkaloids extracted from poppy pods and their semi-synthetic counterparts, which bind to the opiate receptors. These including opium, codeine and morphine.

Semisynthetic opiates/opioids are derived by altering chemicals contained in opium. Some semi-synthetics include hydrocodone, oxycodone, buprenorphine and diamorphine (heroin). Naloxone is also a semi-synthetic opioid, although it is an opioid antagonist, not an agonist.

"Opioid" refers to any drug which binds to the opioid receptors. Opioids include all of the opiates as well as any synthesized drug that attaches itself to the CNS or gastrointestinal tract opioid receptors.

Opioids include codiene, morphine, diamorphine, hydrocodone, oxycodone, hydromorphone, oxymorphone, buprenorphine, methadone, fentanyl, etc.

Some synthetic (man-made) opioids include methadone, pethidine (Demerol) fentanyl, tramadol (Ultram), and loperamide (Imodium).