Ortho Tri-Cyclen the regular not the Lo version is the only thing that cleared my acne, I had big cystic pimples on my chin nose and forehead. I havent broken out like that in about a year, because of OTC. I tried the Lo version and my acne came back. This is what works for me, it could work for you it may not. What did not work for me was Desogen or Alesse. It took about 4 months to see much improvement and 6 months till I was completely clear. Again this is just my experiance yours may be different.