I have severe to chronic daily skeletal and muscular pain due to arthritis and surgical repair damage to body tissue. All various types of non-drug treatment has failed to relieve the daily chronic/severe pain. I am thus on a life-time senario of long-term daily use of a drug therapy (30 yrs). The drug combination is for muscle relaxant combined with pain relief and is based on a fixed daily dose of 3 x 5mg = 15mg Diazepam (muscle relaxant) plus 3 x 50mg = 150mg Tramadol (for pain relief). As this is a life-time use I am concerned about the long-term effects on kidney and liver function in processing the daily dose. Can anyone advise if there is an alternative safer drug combination or provide information with regards to whether this drug combination will cause kidney/liver damage over a long-term use? At this dose level I have no addiction or tolerance problems, however, I am 100% dependent for quality of life with a pain level less than 2 out of 10 (max). As I have tried many other alternative drug combinations I have found that this combination is the only combination that gives me the right quality life for the medical conditions that I am suffering, however, I am concerned about kidney/liver damage over the long-term use, can anyone advise the way forward? Todate I have no information on the long-term use of Tramadol.